Minocin and Metformin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Minocin (minocycline hydrochloride) and Metformin (metformin hydrochloride). Common drug interactions include impulsive behaviour among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Minocin and Metformin. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Minocin?

Minocin has active ingredients of minocycline hydrochloride. It is often used in acne. eHealthMe is studying from 2,278 Minocin users. Check the latest studies of Minocin.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.



On Jul, 06, 2026

44 people who take Minocin and Metformin together, and have interactions are studied.

Minocin and Metformin drug interactions.

What are the common drug interactions of Minocin and Metformin, by gender? *:

female:

  1. Impulsive behaviour
  2. Injury
  3. Lip pain
  4. Loss of employment
  5. Menstrual disorder (disease of menstrual cycle)
  6. Mouth ulceration (mouth ulcers)
  7. Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
  8. Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
  9. Ovarian cyst ruptured (tear in fluid filled sac of the ovary)
  10. Personality disorder

male:

  1. Diarrhoea
  2. Blood glucose increased
  3. Adverse reaction
  4. Drug ineffective
  5. International normalised ratio increased
  6. Lymphoma (cancer that begins in immune system cells)
  7. Malignant neoplasm progression (cancer tumour came back)
  8. Nasopharyngitis (inflammation of the nasopharynx)
  9. Renal failure (kidney dysfunction)
  10. Weight decreased

What are the common drug interactions of Minocin and Metformin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Abdominal pain lower
  2. Alanine aminotransferase increased
  3. Albumin urine present
  4. Anxiety
  5. Compulsive shopping
  6. Constipation
  7. Cough
  8. Diarrhoea
  9. Dysplasia (enlargement of an organ or tissue)
  10. Eating disorder

30-39:

  1. Pain
  2. Abdominal pain upper
  3. Abscess (pus)
  4. Anxiety
  5. Apathy
  6. Arthralgia (joint pain)
  7. Asthenia (weakness)
  8. Atelectasis (partial or complete collapse of the lung)
  9. Blood testosterone increased
  10. Burning sensation

40-49:

  1. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  2. Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)
  3. C-reactive protein increased
  4. Confusional state
  5. Drug hypersensitivity
  6. Dyspnoea (difficult or laboured respiration)
  7. Injection site reaction
  8. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  9. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
  10. Peripheral swelling

50-59:

  1. Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
  2. Sleep disorder
  3. Thrombocytopenia (decrease of platelets in blood)
  4. Urinary tract infection
  5. Weight increased
  6. Diarrhoea
  7. Blood glucose increased
  8. Clostridial infection (infectious conditions by clostridium bacteria)
  9. Emotional distress
  10. Asthenia (weakness)

60+:

  1. Pneumonia
  2. Acute respiratory distress syndrome
  3. Renal failure (kidney dysfunction)
  4. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  5. Drug hypersensitivity
  6. Fatigue (feeling of tiredness)
  7. Hallucination, visual (seeing things that aren't there)
  8. Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
  9. Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
  10. Barotrauma (injury to body because of changes in barometric (air) or water pressure)

What are the existing conditions these people have? *

  1. Breast Cancer Female: 8 people, 18.18%
  2. Insomnia (sleeplessness): 8 people, 18.18%
  3. High Blood Pressure: 5 people, 11.36%
  4. Skin Infection: 5 people, 11.36%
  5. Breast Cancer: 5 people, 11.36%
  6. Pain: 5 people, 11.36%
  7. High Blood Cholesterol: 4 people, 9.09%
  8. Diabetes Insipidus (diabetes caused by a deficiency of the pituitary hormone vasopressin, which regulates kidney function): 3 people, 6.82%
  9. Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 3 people, 6.82%
  10. Blood Glucose Increased: 3 people, 6.82%

* Approximation only. Some reports may have incomplete information.

Do you take Minocin and Metformin?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Minocin and Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Minocin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Minocin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Metformin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on minocycline hydrochloride and metformin hydrochloride (the active ingredients of Minocin and Metformin, respectively), and Minocin and Metformin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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