Mirabegron and Sitagliptin phosphate drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Mirabegron (mirabegron) and Sitagliptin phosphate (sitagliptin phosphate). Common drug interactions include renal impairment among females and febrile neutropenia among males.
The phase IV clinical study analyzes what interactions people have when they take Mirabegron and Sitagliptin phosphate. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.
What is Mirabegron?
Mirabegron has active ingredients of mirabegron. It is often used in urge incontinence. eHealthMe is studying from 5,414 Mirabegron users. Check the latest studies of Mirabegron.
What is Sitagliptin phosphate?
Sitagliptin phosphate has active ingredients of sitagliptin phosphate. eHealthMe is studying from 3,787 Sitagliptin phosphate users. Check the latest studies of Sitagliptin phosphate.
16 people who take Mirabegron and Sitagliptin phosphate together, and have interactions are studied.

What are the common drug interactions of Mirabegron and Sitagliptin Phosphate, by gender? *:
female:
- Renal impairment (severely reduced kidney function)
- Venous thrombosis limb (blood clot that forms in a vein in the limb)
- Arthralgia (joint pain)
- Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
- Hyperglycaemia (high blood sugar)
- Hypertension (high blood pressure)
- Limb discomfort (discomfort in leg)
- Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
- Pain
- Peripheral swelling
male:
- Febrile neutropenia (fever with reduced white blood cells)
- Ileus paralytic (obstruction of the intestine due to paralysis of the intestinal muscles)
- Disuse syndrome (deterioration of body systems as a result of prescribed or unavoidable inactivity)
- Hypoglycaemia (deficiency of glucose in the bloodstream)
- Marasmus (severe malnutrition characterized by energy deficiency)
- Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
- Performance status decreased
What are the common drug interactions of Mirabegron and Sitagliptin Phosphate, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
n/a
50-59:
- Acidosis (build-up of carbon dioxide in the blood)
- Back pain
- Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
- Diarrhoea
- Hypersensitivity
- Infusion site rash
- Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
- Rash
- Tachycardia (a heart rate that exceeds the range of 100 beats/min)
60+:
- Cardiac failure
- Hypovolaemic shock (shock caused by severe blood or fluid loss)
- Hypoxic-ischaemic encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total)
- Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
- Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
- Seizure (abnormal excessive or synchronous neuronal activity in the brain)
- Bacterial test positive
- Brain natriuretic peptide increased
- Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
- Disuse syndrome (deterioration of body systems as a result of prescribed or unavoidable inactivity)
What are the existing conditions these people have? *
- High Blood Pressure: 5 people, 31.25%
- Diabetes: 5 people, 31.25%
- Dementia (madness): 5 people, 31.25%
- Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 5 people, 31.25%
- Asthma: 4 people, 25.00%
- Pneumonia: 4 people, 25.00%
- Osteoporosis (bones weak and more likely to break): 4 people, 25.00%
- Malaise (a feeling of general discomfort or uneasiness): 4 people, 25.00%
- Constipation: 4 people, 25.00%
- Hyperglycemia (high blood sugar): 4 people, 25.00%
* Approximation only. Some reports may have incomplete information.
Do you take Mirabegron and Sitagliptin phosphate?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Mirabegron (5,414 reports)
- Sitagliptin phosphate (3,787 reports)
Browse all drug interactions of Mirabegron and Sitagliptin phosphate:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Mirabegron:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Sitagliptin phosphate:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Mirabegron and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Sitagliptin phosphate and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Liao KF, Lin CL, Lai SW, Chen WC, "Sitagliptin use and risk of acute pancreatitis in type 2 diabetes mellitus: a population-based case-control study in Taiwan", European journal of internal medicine, 2016 Jan .
- Belice T, Yuce S, Kizilkaya B, Kurt A, Cure E, "Noncardiac pulmonary edema induced by sitagliptin treatment", Journal of family medicine and primary care, 2014 Jan .
- Misgar, R. A., Bhat, J. A., Wani, A. I., & Bashir, M. I., "Sitagliptin induced splenic infarcts", Clinical Diabetology, 2014 Jan .
- Stricklin SM, Stoecker WV, Rader RK, Hood AF, Litt JZ, Schuman TP, "Persistent edematous-plaque photosensitivity observed with sitagliptin phosphate (Januvia?)", Dermatology online journal, 2012 Feb .
- Liao KF, Lin CL, Lai SW, Chen WC, "Sitagliptin use and risk of acute pancreatitis in type 2 diabetes mellitus: a population-based case-control study in Taiwan", European journal of internal medicine, 2016 Jan .
- Belice T, Yuce S, Kizilkaya B, Kurt A, Cure E, "Noncardiac pulmonary edema induced by sitagliptin treatment", Journal of family medicine and primary care, 2014 Jan .
- Misgar, R. A., Bhat, J. A., Wani, A. I., & Bashir, M. I., "Sitagliptin induced splenic infarcts", Clinical Diabetology, 2014 Jan .
- Stricklin SM, Stoecker WV, Rader RK, Hood AF, Litt JZ, Schuman TP, "Persistent edematous-plaque photosensitivity observed with sitagliptin phosphate (Januvia?)", Dermatology online journal, 2012 Feb .
How the study uses the data?
The study uses data from the FDA. It is based on mirabegron and sitagliptin phosphate (the active ingredients of Mirabegron and Sitagliptin phosphate, respectively), and Mirabegron and Sitagliptin phosphate (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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