Modafinil and Combivent drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Modafinil (modafinil) and Combivent (albuterol sulfate; ipratropium bromide). Common drug interactions include bradycardia among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Modafinil and Combivent. It is created by eHealthMe based on reports of 86 people who take the same drugs from the FDA, and is updated regularly.

What is Modafinil?

Modafinil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 20,805 Modafinil users. Check the latest studies of Modafinil.

What is Combivent?

Combivent has active ingredients of albuterol sulfate; ipratropium bromide. It is often used in asthma. eHealthMe is studying from 35,341 Combivent users. Check the latest studies of Combivent.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 17, 2026

86 people who take Modafinil and Combivent together, and have interactions are studied.

Modafinil and Combivent drug interactions.

What are the common drug interactions of Modafinil and Combivent, by gender? *:

female:

Bradycardia (abnormally slow heart action)
Cataplexy (loss of muscle tone accompanied by full conscious awareness)
Cerebrospinal fluid leakage
Csf pressure increased
Fluid retention (an abnormal accumulation of fluid in the blood)
Hypotension (abnormally low blood pressure)
Hypoxia (low oxygen in tissues)
Platypnoea (shortness of breath (dyspnea) that is relieved when lying down, and worsens when sitting or standing.)
Somnambulism (sleep walking)
Swelling

male:

Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypertension (high blood pressure)
Libido increased (increased sexual urge to have sex)
Pain
Therapeutic response unexpected
Abnormal sleep-related event
Allergic sinusitis
Depression
Disability

What are the common drug interactions of Modafinil and Combivent, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chills (felling of cold)
Depression
Dysuria (painful or difficult urination)
Feeling hot
Hypoacusis (loss of hearing)
Immune system disorder
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscle spasms (muscle contraction)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)

40-49:

Aneurysm (enlargement of an artery caused by a weakening of the artery wall)
Asthenia (weakness)
Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)
Cerebrospinal fluid leakage
Csf pressure increased
Depressed mood
Depression
Eosinophilia (eosinophil count in the peripheral blood exceeds)
Fall

50-59:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood cholesterol decreased
Drug ineffective
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Somnambulism (sleep walking)
Swelling
Blood potassium decreased
Cataplexy (loss of muscle tone accompanied by full conscious awareness)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Extrasystoles

60+:

Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Folate deficiency (lack of folic acid)
Hospitalisation
Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
Muscle spasms (muscle contraction)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pain
Pneumonia
Restless legs syndrome (a powerful urge to move your legs)

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 49 people, 56.98%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 6.98%
Diabetes: 5 people, 5.81%

* Approximation only. Some reports may have incomplete information.

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