Modafinil and Mucinex d drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Modafinil (modafinil) and Mucinex d (guaifenesin; pseudoephedrine hydrochloride). Common drug interactions include cataract among females and hepatic steatosis among males.

The phase IV clinical study analyzes what interactions people have when they take Modafinil and Mucinex d. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Modafinil?

Modafinil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 20,805 Modafinil users. Check the latest studies of Modafinil.

What is Mucinex d?

Mucinex d has active ingredients of guaifenesin; pseudoephedrine hydrochloride. It is often used in sinus congestion. eHealthMe is studying from 1,926 Mucinex d users. Check the latest studies of Mucinex d.

On Jul, 06, 2026

53 people who take Modafinil and Mucinex d together, and have interactions are studied.

Modafinil and Mucinex d drug interactions.

What are the common drug interactions of Modafinil and Mucinex D, by gender? *:

female:

Cataract (clouding of the lens inside the eye)
Gastric bypass
Headache (pain in head)
Hepatic steatosis (fatty liver disease)
Hypertonic bladder (bladder-storage function that causes a sudden urge to urinate)
Hypokalaemia (low potassium)
Intervertebral disc protrusion (spinal disc protrusion)
Knee arthroplasty
Malaise (a feeling of general discomfort or uneasiness)
Muscle spasms (muscle contraction)

male:

Hepatic steatosis (fatty liver disease)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Headache (pain in head)
Adverse drug reaction
Anxiety
Cataract (clouding of the lens inside the eye)
Chest discomfort
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diarrhoea

What are the common drug interactions of Modafinil and Mucinex D, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Fatigue (feeling of tiredness)
Abdominal pain
Asthenia (weakness)
Diarrhoea haemorrhagic (bloody diarrhoea)
Drug ineffective
Hangover
Hypertension (high blood pressure)
Nausea (feeling of having an urge to vomit)
Vomiting
Weight decreased

30-39:

Hypokalaemia (low potassium)
Restless legs syndrome (a powerful urge to move your legs)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

40-49:

Fungal infection
Gastroenteritis (inflammation of stomach and intestine)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hepatic steatosis (fatty liver disease)
Infection
Liver disorder (liver diseases)
Pneumonia bacterial (pneumonia associated with bacterial infection)
Post procedural bile leak
Pyrexia (fever)
Rhinitis allergic (inflammation of the nasal airways due to allergy)

50-59:

Chest pain
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Gastric bypass

60+:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Productive cough
Respiratory tract infection
Sputum discoloured

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 32 people, 60.38%
Drowsiness: 8 people, 15.09%
Immunodeficiency Common Variable: 3 people, 5.66%

* Approximation only. Some reports may have incomplete information.

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