Modafinil and Spravato drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Modafinil (modafinil) and Spravato (esketamine hydrochloride). Common drug interactions include drug ineffective among females and dissociation among males.

The phase IV clinical study analyzes what interactions people have when they take Modafinil and Spravato. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Modafinil?

Modafinil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 20,805 Modafinil users. Check the latest studies of Modafinil.

What is Spravato?

Spravato has active ingredients of esketamine hydrochloride. eHealthMe is studying from 7,920 Spravato users. Check the latest studies of Spravato.

On Aug, 02, 2026

24 people who take Modafinil and Spravato together, and have interactions are studied.

Modafinil and Spravato drug interactions.

What are the common drug interactions of Modafinil and Spravato, by gender? *:

female:

Drug ineffective
Hypertension (high blood pressure)
Weight decreased
Blood pressure decreased
Tendon rupture (tear of tendon)
Tremor (trembling or shaking movements in one or more parts of your body)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Abdominal distension
Balance disorder
Blood sodium decreased

male:

Dissociation
Sedation
Nausea (feeling of having an urge to vomit)
Vomiting
Depression
Completed suicide (act of taking one's own life)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Therapeutic response decreased (less preventive response)
Depressed mood
Hypertension (high blood pressure)

What are the common drug interactions of Modafinil and Spravato, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Depression
Completed suicide (act of taking one's own life)

40-49:

Drug ineffective
Tremor (trembling or shaking movements in one or more parts of your body)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Hypertension (high blood pressure)
Tardive dyskinesia (a disorder that involves involuntary movements)
Weight decreased
Dissociation
Alcoholic
Depression
Dysphagia (a condition in which swallowing is difficult or painful)

50-59:

Depressed mood
Suicidal ideation
Urticaria (rash of round, red welts on the skin that itch intensely)

60+:

Sedation
Dissociation
Brain injury
Diplopia (double vision)
Eye infection
Head injury
Hypotension (abnormally low blood pressure)
Knee arthroplasty
Muscle spasms (muscle contraction)
Non-cardiac chest pain

What are the existing conditions these people have? *

Depression: 13 people, 54.17%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 7 people, 29.17%
Stress And Anxiety: 6 people, 25.00%
Drowsiness: 5 people, 20.83%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 16.67%
Tremor (trembling or shaking movements in one or more parts of your body): 3 people, 12.50%
Insomnia (sleeplessness): 3 people, 12.50%
Affective Disorder (mental disorder): 3 people, 12.50%
Suicidal Ideation: 2 people, 8.33%
Pain: 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Modafinil and Spravato?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously