Morphine sulfate and Alphagan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Morphine sulfate (morphine sulfate) and Alphagan (brimonidine tartrate). Common drug interactions include bone disorder among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Morphine sulfate and Alphagan. It is created by eHealthMe based on reports of 84 people who take the same drugs from the FDA, and is updated regularly.

What is Morphine sulfate?

Morphine sulfate has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 87,261 Morphine sulfate users. Check the latest studies of Morphine sulfate.

What is Alphagan?

Alphagan has active ingredients of brimonidine tartrate. It is often used in glaucoma. eHealthMe is studying from 9,981 Alphagan users. Check the latest studies of Alphagan.



On Jul, 15, 2026

84 people who take Morphine sulfate and Alphagan together, and have interactions are studied.

Morphine sulfate and Alphagan drug interactions.

What are the common drug interactions of Morphine Sulfate and Alphagan, by gender? *:

female:

  1. Bone disorder
  2. Dyspnoea (difficult or laboured respiration)
  3. Pain in jaw
  4. Hypoaesthesia (reduced sense of touch or sensation)
  5. Oedema peripheral (superficial swelling)
  6. Bruxism (habitual grinding of the teeth, typically during sleep)
  7. Hip fracture
  8. Pain in extremity
  9. Pleural effusion (water on the lungs)
  10. Osteopenia (a condition where bone mineral density is lower than normal)

male:

  1. Fatigue (feeling of tiredness)
  2. Nausea (feeling of having an urge to vomit)
  3. Myalgia (muscle pain)
  4. Pneumonia
  5. Visual field defect
  6. Apnoea (suspension of external breathing)
  7. Bruxism (habitual grinding of the teeth, typically during sleep)
  8. Hypopnoea (decrease in the breathing rate)
  9. Snoring
  10. Bone disorder

What are the common drug interactions of Morphine Sulfate and Alphagan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Drug hypersensitivity

40-49:

n/a

50-59:

  1. Abdominal pain
  2. Atelectasis (partial or complete collapse of the lung)
  3. Asthenia (weakness)
  4. Constipation
  5. Dizziness
  6. Myalgia (muscle pain)
  7. Abdominal pain upper
  8. Alpha haemolytic streptococcal infection (infections with alpha-haemolytic strep bacteria are common; many strains live naturally in humans)
  9. Bronchitis chronic (inflammation of the mucous membrane in the bronchial tubes- chronic)
  10. Carotid bruit (sound heard over the carotid artery area during auscultation)

60+:

  1. Anxiety
  2. Bruxism (habitual grinding of the teeth, typically during sleep)
  3. Pain in extremity
  4. Visual impairment
  5. Anaemia (lack of blood)
  6. Blood creatinine increased
  7. Confusional state
  8. Hypokalaemia (low potassium)
  9. Oedema peripheral (superficial swelling)
  10. Anhedonia (inability to experience pleasure from activities usually found enjoyable)

What are the existing conditions these people have? *

  1. Multiple Myeloma (cancer of the plasma cells): 14 people, 16.67%
  2. Nausea (feeling of having an urge to vomit): 7 people, 8.33%
  3. Constipation: 7 people, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Morphine sulfate and Alphagan?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Morphine sulfate and Alphagan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Morphine sulfate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Alphagan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Morphine sulfate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Alphagan and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on morphine sulfate and brimonidine tartrate (the active ingredients of Morphine sulfate and Alphagan, respectively), and Morphine sulfate and Alphagan (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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