Morphine and Epival drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Morphine (morphine sulfate) and Epival (divalproex sodium). Common drug interactions include abdominal discomfort among females and cardiac failure among males.

The phase IV clinical study analyzes what interactions people have when they take Morphine and Epival. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Morphine?

Morphine has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 182,913 Morphine users. Check the latest studies of Morphine.

What is Epival?

Epival has active ingredients of divalproex sodium. It is often used in epilepsy. eHealthMe is studying from 1,088 Epival users. Check the latest studies of Epival.

On Jul, 28, 2026

12 people who take Morphine and Epival together, and have interactions are studied.

What are the common drug interactions of Morphine and Epival, by gender? *:

female:

Abdominal discomfort
Dizziness
Dry mouth
Micturition urgency (urgency to pass the urine)
Nausea (feeling of having an urge to vomit)
Oropharyngeal pain
Vomiting
Agitation (state of anxiety or nervous excitement)
Arrhythmia (irregular heartbeat)
Head injury

male:

Cardiac failure
Neutropenia (an abnormally low number of neutrophils)
Thrombocytopenia (decrease of platelets in blood)
White blood cell count decreased
Death
Acute myocardial infarction (acute heart attack)
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Dyspnoea (difficult or laboured respiration)
Ventricular fibrillation (abnormally irregular heart rhythm)
Brachial plexus injury (brachial plexus injuries, are caused by damage to those nerves network that conducts signals from the spinal cord)

What are the common drug interactions of Morphine and Epival, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Infection
Lymphadenopathy (disease or enlargement of lymph nodes)
Nephropathy toxic (damage to kidney due to toxins)
Neutropenia (an abnormally low number of neutrophils)
Sepsis (a severe blood infection that can lead to organ failure and death)
Septic shock (shock due to blood infection)

50-59:

n/a

60+:

Cardiac failure
Bicytopenia (two parameters from the full blood count are low, the term bicytopenia can be used)
Thrombocytopenia (decrease of platelets in blood)
White blood cell count decreased
Death
Acute myocardial infarction (acute heart attack)
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Dyspnoea (difficult or laboured respiration)
Ventricular fibrillation (abnormally irregular heart rhythm)
Brachial plexus injury (brachial plexus injuries, are caused by damage to those nerves network that conducts signals from the spinal cord)

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 25.00%
Tonsil Cancer: 2 people, 16.67%
Facial Pain: 2 people, 16.67%
Depression: 2 people, 16.67%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 2 people, 16.67%
Schizophrenia, Paranoid Type (delusions and auditory hallucinations but relatively normal intellectual functioning and expression of affect): 1 person, 8.33%
Psychotic Disorder: 1 person, 8.33%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 1 person, 8.33%
High Blood Pressure: 1 person, 8.33%
Dyslipidaemia (abnormal amount of lipids): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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