Morphine and Lotronex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Morphine (morphine sulfate) and Lotronex (alosetron hydrochloride). Common drug interactions include colonic perforation among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Morphine and Lotronex. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Morphine?

Morphine has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 182,913 Morphine users. Check the latest studies of Morphine.

What is Lotronex?

Lotronex has active ingredients of alosetron hydrochloride. It is often used in irritable bowel syndrome. eHealthMe is studying from 6,841 Lotronex users. Check the latest studies of Lotronex.

On Jul, 08, 2026

19 people who take Morphine and Lotronex together, and have interactions are studied.

Morphine and Lotronex drug interactions.

What are the common drug interactions of Morphine and Lotronex, by gender? *:

female:

Colonic perforation (a hole in the colon)
Diarrhoea
Faeces hard
Hydronephrosis (water inside the kidney)
Hypotension (abnormally low blood pressure)
Nausea (feeling of having an urge to vomit)
Rectal haemorrhage (bleeding from anus)
Sepsis (a severe blood infection that can lead to organ failure and death)
Vomiting
Abdominal distension

male:

Abdominal pain
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Abnormal dreams
Agitation (state of anxiety or nervous excitement)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Arthralgia (joint pain)
Asthenia (weakness)
Asthma
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chest pain

What are the common drug interactions of Morphine and Lotronex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Mitral valve prolapse (heart's mitral valve doesn't work well)
Nervousness
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Polyuria (production of too much dilute urine)
Red blood cell count decreased
Sepsis (a severe blood infection that can lead to organ failure and death)
Tricuspid valve incompetence (inefficient heart valve)
Vomiting
Abdominal distension
Alcohol poisoning

40-49:

Constipation
Depression
Diarrhoea
Faeces discoloured
Fatigue (feeling of tiredness)
Insomnia (sleeplessness)
Lethargy (tiredness)
Nausea (feeling of having an urge to vomit)
Vomiting
Weight decreased

50-59:

n/a

60+:

Abdominal pain
Anaemia (lack of blood)
Constipation
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematemesis (vomiting of blood)
Swelling

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 10.53%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 5.26%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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