Morphine and Mysoline drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Morphine (morphine sulfate) and Mysoline (primidone). Common drug interactions include dental caries among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Morphine and Mysoline. It is created by eHealthMe based on reports of 76 people who take the same drugs from the FDA, and is updated regularly.

What is Morphine?

Morphine has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 182,913 Morphine users. Check the latest studies of Morphine.

What is Mysoline?

Mysoline has active ingredients of primidone. It is often used in essential tremor. eHealthMe is studying from 2,849 Mysoline users. Check the latest studies of Mysoline.

On Jul, 19, 2026

76 people who take Morphine and Mysoline together, and have interactions are studied.

Morphine and Mysoline drug interactions.

What are the common drug interactions of Morphine and Mysoline, by gender? *:

female:

Dental caries
Disability
Dyskinesia (abnormality or impairment of voluntary movement)
Dysphagia (a condition in which swallowing is difficult or painful)
Fatigue (feeling of tiredness)
Fracture nonunion (permanent failure of healing following a broken bone)
Gingivitis (inflammation of gums)
Iron deficiency anaemia
Jaw fracture
Malaise (a feeling of general discomfort or uneasiness)

male:

Fatigue (feeling of tiredness)
Infection
Cellulitis (infection under the skin)
Cyst (a closed sac)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Fistula (an abnormal connection or passageway between two)
Gingivitis (inflammation of gums)
Hepatomegaly (abnormal enlargement of the liver)
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection)
Impaired healing

What are the common drug interactions of Morphine and Mysoline, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Cerebral haemorrhage (bleeding within the brain)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)

10-19:

n/a

20-29:

Sepsis (a severe blood infection that can lead to organ failure and death)
Ear infection
Eye infection
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Pseudomonas test positive
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose)
Chronic tonsillitis (long lasting inflammation of tonsil)
Infection
Pneumonia
Respiratory tract infection

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Asthenia (weakness)
Bone callus excessive (excessive bony deposit formed between and around the broken ends of bone fractures)
Bruxism (habitual grinding of the teeth, typically during sleep)
Cardiovascular disorder (heart diseases)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cranial nerve disorder (impaired functioning of one of the twelve cranial nerves)
Dental caries
Disability

40-49:

Cardiovascular disorder (heart diseases)
Chronic tonsillitis (long lasting inflammation of tonsil)
Confusional state
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Diplopia (double vision)
Drug abuse
Dyspepsia (indigestion)
Fall
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

50-59:

Cystitis (inflammation of the wall of the bladder)
Herpes simplex (herpes simplex is a common viral infection)
Small intestinal obstruction (blockage in small intestine)
Cardiovascular disorder (heart diseases)
Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Drug ineffective
Fibromyalgia (a long-term condition which causes pain all over the body)
Hearing impaired
Oedema peripheral (superficial swelling)
Osteoporosis (bones weak and more likely to break)

60+:

Fall
Fatigue (feeling of tiredness)
Bone disorder
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Cellulitis (infection under the skin)
Cyst (a closed sac)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Fistula (an abnormal connection or passageway between two)
Gingivitis (inflammation of gums)
Hepatomegaly (abnormal enlargement of the liver)

What are the existing conditions these people have? *

High Blood Pressure: 18 people, 23.68%
Stress And Anxiety: 13 people, 17.11%
Multiple Myeloma (cancer of the plasma cells): 12 people, 15.79%
Depression: 9 people, 11.84%
Back Pain: 8 people, 10.53%
Nausea (feeling of having an urge to vomit): 8 people, 10.53%
Hypokalemia (low potassium): 8 people, 10.53%
Tremor (trembling or shaking movements in one or more parts of your body): 7 people, 9.21%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 7 people, 9.21%
Blood Iron Decreased: 7 people, 9.21%

* Approximation only. Some reports may have incomplete information.

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