Morphine and Nicotinic acid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Morphine (morphine sulfate) and Nicotinic acid (niacin and niacinamide (vitamin b3)). Common drug interactions include chills among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Morphine and Nicotinic acid. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Morphine?

Morphine has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 182,914 Morphine users. Check the latest studies of Morphine.

What is Nicotinic acid?

Nicotinic acid has active ingredients of niacin and niacinamide (vitamin b3). It is often used in high blood cholesterol. eHealthMe is studying from 842 Nicotinic acid users. Check the latest studies of Nicotinic acid.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

15 people who take Morphine and Nicotinic acid together, and have interactions are studied.

Morphine and Nicotinic acid drug interactions.

What are the common drug interactions of Morphine and Nicotinic Acid, by gender? *:

female:

Chills (felling of cold)
Constipation
Cough
Crying
Depression
Drug administration error
Drug ineffective
Dysphonia (speech disorder attributable to a disorder of phonation)
Fear of eating
Gastrointestinal motility disorder (abnormal intestinal contractions)

male:

Dyspnoea (difficult or laboured respiration)
Agitation (state of anxiety or nervous excitement)
Lethargy (tiredness)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Overdose
Pyrexia (fever)
Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease)
Somnolence (a state of near-sleep, a strong desire for sleep)
Unresponsive to stimuli
Abdominal pain

What are the common drug interactions of Morphine and Nicotinic Acid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal pain
Abdominal pain upper
Chest pain
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Flatulence (flatus expelled through the anus)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Vision blurred
Vomiting

50-59:

Acute respiratory failure
Agitation (state of anxiety or nervous excitement)
Apnoea (suspension of external breathing)
Breath sounds absent
Confusional state
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dyspnoea (difficult or laboured respiration)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Lethargy (tiredness)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

60+:

Nausea (feeling of having an urge to vomit)
Sepsis (a severe blood infection that can lead to organ failure and death)
Cough
Crying
Drug administration error
Drug ineffective
Dysphonia (speech disorder attributable to a disorder of phonation)
Fear of eating
Gastrointestinal motility disorder (abnormal intestinal contractions)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)

What are the existing conditions these people have? *

Pemphigoid (tense blisters on the skin): 2 people, 13.33%
Back Pain: 2 people, 13.33%
Hyperkalemia (damage to or disease of the kidney): 2 people, 13.33%
Type 2 Diabetes: 1 person, 6.67%
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood): 1 person, 6.67%
Adenocarcinoma (malignant tumour formed from glandular structures in epithelial tissue): 1 person, 6.67%
Allergies: 1 person, 6.67%
Anaemia (lack of blood): 1 person, 6.67%
Anaesthesia: 1 person, 6.67%
Ankylosing Spondylitis (type of arthritis affecting the spine): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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