Morphine and Promethazine w/ codeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Morphine (morphine sulfate) and Promethazine w/ codeine (codeine phosphate; promethazine hydrochloride). Common drug interactions include multi-organ failure among females and actinomycosis among males.

The phase IV clinical study analyzes what interactions people have when they take Morphine and Promethazine w/ codeine. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Morphine?

Morphine has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 182,913 Morphine users. Check the latest studies of Morphine.

What is Promethazine w/ codeine?

Promethazine w/ codeine has active ingredients of codeine phosphate; promethazine hydrochloride. It is often used in cough. eHealthMe is studying from 279 Promethazine w/ codeine users. Check the latest studies of Promethazine w/ codeine.

On Jul, 20, 2026

22 people who take Morphine and Promethazine w/ codeine together, and have interactions are studied.

Morphine and Promethazine w/ codeine drug interactions.

What are the common drug interactions of Morphine and Promethazine W/ Codeine, by gender? *:

female:

Multi-organ failure (multisystem organ failure)
Pericardial effusion (fluid around the heart)
Presyncope
Renal failure (kidney dysfunction)
Sinusitis (inflammation of sinus)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Tuberculin test positive
Uterine cancer
Abdominal pain upper
Anaemia (lack of blood)

male:

Actinomycosis (infection that causes sores, or abscesses)
Alveolar osteitis (complication of wound healing following extraction of a tooth)
Cerebral atrophy (decrement in size of brain)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Decreased activity
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diarrhoea
Disease progression
Dysgeusia (disorder of the sense of taste)

What are the common drug interactions of Morphine and Promethazine W/ Codeine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Presyncope
Renal failure (kidney dysfunction)
Sinusitis (inflammation of sinus)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Tuberculin test positive
Uterine cancer
Abdominal pain upper
Atelectasis (partial or complete collapse of the lung)
Blood cholesterol increased
Blood glucose increased

30-39:

n/a

40-49:

n/a

50-59:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Alveolar osteitis (complication of wound healing following extraction of a tooth)
Arthralgia (joint pain)
Balance disorder
Blood creatinine increased
Bone disorder
Breath odour
Cardiac arrest
Cataract (clouding of the lens inside the eye)
Cerebral atrophy (decrement in size of brain)

60+:

Myelitis transverse (a neurological condition consisting of an inflammatory process of the spinal cord)

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 9 people, 40.91%
Sleep Disorder: 3 people, 13.64%
Nausea (feeling of having an urge to vomit): 3 people, 13.64%
Nasal Discharge (discharge from nose): 3 people, 13.64%
Mantle Cell Lymphoma (cancer of lymphocytes, a type of white blood cell): 3 people, 13.64%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 13.64%
Peripartum Cardiomyopathy (deterioration in cardiac function presenting typically between the last month of pregnancy and up to five months postpartum): 2 people, 9.09%
Osteoporosis (bones weak and more likely to break): 2 people, 9.09%
Migraine (headache): 2 people, 9.09%
Insomnia (sleeplessness): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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