Msm and Folic acid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Msm (methylsulfonylmethane) and Folic acid (folic acid). Common drug interactions include injection site swelling among females and erectile dysfunction among males.

The phase IV clinical study analyzes what interactions people have when they take Msm and Folic acid. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Msm?

Msm has active ingredients of methylsulfonylmethane. It is often used in joint pain. eHealthMe is studying from 1,210 Msm users. Check the latest studies of Msm.

What is Folic acid?

Folic acid has active ingredients of folic acid. It is often used in rheumatoid arthritis. eHealthMe is studying from 165,027 Folic acid users. Check the latest studies of Folic acid.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 15, 2026

29 people who take Msm and Folic acid together, and have interactions are studied.

What are the common drug interactions of Msm and Folic Acid, by gender? *:

female:

Injection site swelling
Keratoconjunctivitis sicca (inflammation of the conjunctiva and cornea of the eye with decreased tears)
Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Oedema (fluid collection in tissue)
Pain in extremity
Pyrexia (fever)
Rhinorrhoea (watery mucus discharge from the nose)
Sepsis (a severe blood infection that can lead to organ failure and death)
Skin discolouration (change of skin colour)
Subdural haematoma (blood collects between the skull and the surface of the brain)

male:

Erectile dysfunction
Mobility decreased (ability to move is reduced)
Fungal infection
Gait disturbance
Injection site bruising
Injection site pain
Lacrimation increased
Localised infection (infection at the single location)
Muscular weakness (muscle weakness)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

What are the common drug interactions of Msm and Folic Acid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abortion spontaneous (naturally occurring miscarriage)
Anti-cyclic citrullinated peptide antibody positive
Back pain
Decreased appetite
Headache (pain in head)
Inflammatory marker increased
Joint effusion (presence of extra fluid in joint covering)
Joint range of motion decreased (disease of joint movement)
Joint stiffness
Joint swelling

30-39:

n/a

40-49:

Injection site erythema (redness at injection site)

50-59:

n/a

60+:

Nausea (feeling of having an urge to vomit)
Pain
Cough
Drug ineffective
Erectile dysfunction
Eye disorder
Feeling cold
Impaired driving ability
Infusion related reaction
Injection site erythema (redness at injection site)

What are the existing conditions these people have? *

High Blood Cholesterol: 3 people, 10.34%
Pain: 2 people, 6.90%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 2 people, 6.90%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 6.90%
Cardiac Disorder: 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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