Mucinex and Arava drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mucinex (guaifenesin) and Arava (leflunomide). Common drug interactions include arthralgia among females and brain injury among males.

The phase IV clinical study analyzes what interactions people have when they take Mucinex and Arava. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Mucinex?

Mucinex has active ingredients of guaifenesin. It is often used in cough. eHealthMe is studying from 29,749 Mucinex users. Check the latest studies of Mucinex.

What is Arava?

Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 76,040 Arava users. Check the latest studies of Arava.

On Jul, 20, 2026

50 people who take Mucinex and Arava together, and have interactions are studied.

What are the common drug interactions of Mucinex and Arava, by gender? *:

female:

Arthralgia (joint pain)
Cellulitis (infection under the skin)
Cellulitis streptococcal (deep skin soft tissue infection by bacteria)
Chest pain
Drug hypersensitivity
Drug ineffective
Dry mouth
Dyspepsia (indigestion)
Fuchs' syndrome (eye disease affecting the cornea)
Hallucination (an experience involving the perception of something not present)

male:

Brain injury
Decreased appetite
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Back pain
Bacterial infection
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Bursitis infective (the bursa can become infected, this is called infected bursitis)

What are the common drug interactions of Mucinex and Arava, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abortion induced (medically referred abortion)
Pregnancy on contraceptive

30-39:

n/a

40-49:

Brain injury
Decreased appetite
Wound infection
Infection
Sinusitis (inflammation of sinus)
Weight fluctuation
Headache (pain in head)
Amyotrophic lateral sclerosis (nervous system disease that attacks nerve cells called neurons in your brain and spinal cord)
Craniocerebral injury (injury to cranium and brain)
Sinus node dysfunction (a group of abnormal heart rhythms)

50-59:

Joint stiffness
Joint swelling
Lymph node pain
Lymphadenitis bacterial (bacterial infection of lymph nodes)
Lymphadenopathy (disease or enlargement of lymph nodes)
Mouth ulceration (mouth ulcers)
Muscular weakness (muscle weakness)
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Neuropathy peripheral (surface nerve damage)

60+:

Pain
Arthralgia (joint pain)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
B-cell lymphoma (blood cancer affecting b cells)
Back pain
Bacterial infection
Breast cancer
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bronchitis chronic (inflammation of the mucous membrane in the bronchial tubes- chronic)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 11 people, 22.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 14.00%
High Blood Cholesterol: 6 people, 12.00%
Pain: 4 people, 8.00%
Hypersensitivity: 4 people, 8.00%
High Blood Pressure: 4 people, 8.00%
Primary Immunodeficiency Syndrome: 3 people, 6.00%
Joint Pain: 3 people, 6.00%
Indigestion: 3 people, 6.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 6.00%

* Approximation only. Some reports may have incomplete information.

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