Multihance and Metformin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Multihance (gadobenate dimeglumine) and Metformin (metformin hydrochloride). Common drug interactions include syncope among females and nephrogenic systemic fibrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Multihance and Metformin. It is created by eHealthMe based on reports of 66 people who take the same drugs from the FDA, and is updated regularly.

What is Multihance?

Multihance has active ingredients of gadobenate dimeglumine. eHealthMe is studying from 5,786 Multihance users. Check the latest studies of Multihance.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,358 Metformin users. Check the latest studies of Metformin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

66 people who take Multihance and Metformin together, and have interactions are studied.

Multihance and Metformin drug interactions.

What are the common drug interactions of Multihance and Metformin, by gender? *:

female:

Syncope (loss of consciousness with an inability to maintain postural tone)
Emotional distress
Injury
Joint swelling
Lower extremity mass (mass in lower legs)
Mobility decreased (ability to move is reduced)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Rash
Skin discolouration (change of skin colour)

male:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
General physical health deterioration (weak health status)
Rash
Pain in extremity
Depression
Injury
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Skin fibrosis (fibrous tissue formation on skin)
Bone pain
Cardiac disorder

What are the common drug interactions of Multihance and Metformin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Urticaria (rash of round, red welts on the skin that itch intensely)
Alopecia (absence of hair from areas of the body)
Bone pain
Burning sensation
Eye irritation
Headache (pain in head)
Photophobia (extreme sensitivity to light)
Wound
Anxiety
Arthralgia (joint pain)

50-59:

Nausea (feeling of having an urge to vomit)
Anaphylactic reaction (serious allergic reaction)
Balance disorder
Malaise (a feeling of general discomfort or uneasiness)
Pulse absent
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Vomiting
Arthralgia (joint pain)
Blood pressure increased
Deafness

60+:

Arthralgia (joint pain)
General physical health deterioration (weak health status)
Emotional distress
Liver disorder (liver diseases)
Mobility decreased (ability to move is reduced)
Renal disorder (kidney disease)
Renal failure (kidney dysfunction)
Skin disorder (skin disease)
Skin fibrosis (fibrous tissue formation on skin)
Syncope (loss of consciousness with an inability to maintain postural tone)

What are the existing conditions these people have? *

Nuclear Magnetic Resonance Imaging Brain: 16 people, 24.24%
Weakness: 8 people, 12.12%
Dizziness: 8 people, 12.12%

* Approximation only. Some reports may have incomplete information.

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