Mysoline and Metformin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mysoline (primidone) and Metformin (metformin hydrochloride). Common drug interactions include dyspnoea among females and tremor among males.

The phase IV clinical study analyzes what interactions people have when they take Mysoline and Metformin. It is created by eHealthMe based on reports of 76 people who take the same drugs from the FDA, and is updated regularly.

What is Mysoline?

Mysoline has active ingredients of primidone. It is often used in essential tremor. eHealthMe is studying from 2,849 Mysoline users. Check the latest studies of Mysoline.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

On Jul, 27, 2026

76 people who take Mysoline and Metformin together, and have interactions are studied.

Mysoline and Metformin drug interactions.

What are the common drug interactions of Mysoline and Metformin, by gender? *:

female:

Dyspnoea (difficult or laboured respiration)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Cytolytic hepatitis (dissolution or destruction of a liver cell)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Drug ineffective
Fatigue (feeling of tiredness)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Sepsis (a severe blood infection that can lead to organ failure and death)

male:

Tremor (trembling or shaking movements in one or more parts of your body)
Drug ineffective
Hypokinesia (decreased bodily movement)
Renal failure (kidney dysfunction)
Diabetes mellitus inadequate control
Pain
Pruritus (severe itching of the skin)
Abnormal behaviour
Acidosis (build-up of carbon dioxide in the blood)
Adverse drug reaction

What are the common drug interactions of Mysoline and Metformin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Burning sensation
Drug ineffective
Gout (uric acid crystals building up in the body)
Peripheral swelling
Pruritus (severe itching of the skin)

40-49:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Drug ineffective
Fall
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)

50-59:

Acidosis (build-up of carbon dioxide in the blood)
Adverse drug reaction
Agitation (state of anxiety or nervous excitement)
Alcohol use
Anger
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Atelectasis (partial or complete collapse of the lung)
Bipolar disorder (mood disorder)
Blood lactic acid increased

60+:

Drug ineffective
Hyperhidrosis (abnormally increased sweating)
Hypertensive crisis
Hypokinesia (decreased bodily movement)
Malaise (a feeling of general discomfort or uneasiness)
Renal failure (kidney dysfunction)
Dyspnoea (difficult or laboured respiration)
Weight decreased
Chronic kidney disease
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)

What are the existing conditions these people have? *

High Blood Pressure: 18 people, 23.68%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 10.53%
High Blood Cholesterol: 8 people, 10.53%
Essential Tremor: 6 people, 7.89%
Headache (pain in head): 6 people, 7.89%
Nausea (feeling of having an urge to vomit): 6 people, 7.89%
Wheezing (a high-pitched whistling sound made while you breath): 5 people, 6.58%
Tremor (trembling or shaking movements in one or more parts of your body): 5 people, 6.58%
Depression: 5 people, 6.58%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 5 people, 6.58%

* Approximation only. Some reports may have incomplete information.

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