Nac and Adderall drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nac (n - acetyl cysteine) and Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate). Common drug interactions include nausea among females and antisocial behaviour among males.

The phase IV clinical study analyzes what interactions people have when they take Nac and Adderall. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Nac?

Nac has active ingredients of n - acetyl cysteine. eHealthMe is studying from 858 Nac users. Check the latest studies of Nac.

What is Adderall?

Adderall has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 64,226 Adderall users. Check the latest studies of Adderall.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

25 people who take Nac and Adderall together, and have interactions are studied.

What are the common drug interactions of Nac and Adderall, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Headache (pain in head)
Abdominal pain upper
Fatigue (feeling of tiredness)
Insomnia (sleeplessness)
Heart rate increased
Pain
Cough
Drug ineffective
Hypophagia (reduced food intake)

male:

Antisocial behaviour
Anxiety
Drug level below therapeutic
Impaired work ability
Quality of life decreased
Suicidal ideation
Surgery
Diplopia (double vision)
Fatigue (feeling of tiredness)
Headache (pain in head)

What are the common drug interactions of Nac and Adderall, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Adverse event
Insomnia (sleeplessness)

20-29:

n/a

30-39:

Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Antisocial behaviour
Anxiety
Diplopia (double vision)
Fatigue (feeling of tiredness)
Heart rate increased
Hyperhidrosis (abnormally increased sweating)
Loss of employment
Pain

40-49:

Alopecia (absence of hair from areas of the body)
Crying
Diplopia (double vision)
Fatigue (feeling of tiredness)
Headache (pain in head)
Hypophagia (reduced food intake)
Thrombosis (formation of a blood clot inside a blood vessel)
Tremor (trembling or shaking movements in one or more parts of your body)
Weight increased

50-59:

Abdominal pain upper
Chest discomfort
Eye pain
Headache (pain in head)
Impaired work ability
Insomnia (sleeplessness)
Libido increased (increased sexual urge to have sex)
Nausea (feeling of having an urge to vomit)
Quality of life decreased
Sensory disturbance (sense disturbance)

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 20.00%
Depression: 3 people, 12.00%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 12.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 12.00%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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