Nac and Naltrexone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nac (n - acetyl cysteine) and Naltrexone (naltrexone). Common drug interactions include fatigue among females.

The phase IV clinical study analyzes what interactions people have when they take Nac and Naltrexone. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Nac?

Nac has active ingredients of n - acetyl cysteine. eHealthMe is studying from 858 Nac users. Check the latest studies of Nac.

What is Naltrexone?

Naltrexone has active ingredients of naltrexone. eHealthMe is studying from 4,835 Naltrexone users. Check the latest studies of Naltrexone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

12 people who take Nac and Naltrexone together, and have interactions are studied.

What are the common drug interactions of Nac and Naltrexone, by gender? *:

female:

Fatigue (feeling of tiredness)
Headache (pain in head)
Infusion related reaction
Infusion site extravasation (flow of (blood or lymph) from infusion site)
Migraine (headache)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Ear congestion
Hypotension (abnormally low blood pressure)
Nausea (feeling of having an urge to vomit)
Rash

male:

n/a

What are the common drug interactions of Nac and Naltrexone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Dizziness
Feeling cold
Hyperhidrosis (abnormally increased sweating)
Influenza like illness
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)

30-39:

n/a

40-49:

Dizziness
Pain
Arthralgia (joint pain)
Asthma
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Device occlusion
Ear congestion
Fall
Fatigue (feeling of tiredness)
Headache (pain in head)

50-59:

n/a

60+:

Dysphonia (speech disorder attributable to a disorder of phonation)
Ear pain
Oral herpes (viral infection of mouth)
Oropharyngeal pain
Productive cough
Rash
Respiratory tract infection
Rhinorrhoea (watery mucus discharge from the nose)
Sinusitis (inflammation of sinus)
Sneezing

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 7 people, 58.33%
Immune System Disorder: 6 people, 50.00%
B-Lymphocyte Abnormalities (abnormal population of b lymphocytes in the blood, bone marrow, or tissues): 6 people, 50.00%
Asthma: 4 people, 33.33%
Urinary Tract Infection: 1 person, 8.33%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 1 person, 8.33%
Bipolar Disorder (mood disorder): 1 person, 8.33%
Alcoholism (problems with alcohol): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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