Naloxone and Compazine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naloxone (naloxone hydrochloride) and Compazine (prochlorperazine maleate). Common drug interactions include urinary tract infection among females and dehydration among males.

The phase IV clinical study analyzes what interactions people have when they take Naloxone and Compazine. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Naloxone?

Naloxone has active ingredients of naloxone hydrochloride. eHealthMe is studying from 6,425 Naloxone users. Check the latest studies of Naloxone.

What is Compazine?

Compazine has active ingredients of prochlorperazine maleate. It is often used in nausea and vomiting. eHealthMe is studying from 13,646 Compazine users. Check the latest studies of Compazine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

52 people who take Naloxone and Compazine together, and have interactions are studied.

Naloxone and Compazine drug interactions.

What are the common drug interactions of Naloxone and Compazine, by gender? *:

female:

Urinary tract infection
Infection
Dehydration (dryness resulting from the removal of water)
Hypokalaemia (low potassium)
Pain
Appendicitis (inflammation of the appendix)
Fistula (an abnormal connection or passageway between two)
Haematuria (presence of blood in urine)
Muscle spasms (muscle contraction)
Somnolence (a state of near-sleep, a strong desire for sleep)

male:

Dehydration (dryness resulting from the removal of water)
Dyspnoea (difficult or laboured respiration)
Ear pain
Pain
Abdominal pain upper
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Breast cancer
Decreased interest
Diarrhoea
Dysphonia (speech disorder attributable to a disorder of phonation)

What are the common drug interactions of Naloxone and Compazine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Hypokalaemia (low potassium)
Urinary tract infection
Constipation
Febrile neutropenia (fever with reduced white blood cells)
Gait disturbance
Somnolence (a state of near-sleep, a strong desire for sleep)
Confusional state
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Dysphagia (a condition in which swallowing is difficult or painful)

20-29:

Lung infection

30-39:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Bilirubin conjugated increased
Blood alkaline phosphatase increased
Gamma-glutamyltransferase increased
Abdominal hernia
Abdominal pain
Accident at work
Acute sinusitis
Arthralgia (joint pain)

40-49:

Appendicitis (inflammation of the appendix)
Fistula (an abnormal connection or passageway between two)
Infection
Wound
Anxiety
Depression
Abscess intestinal (collections of pus-intestinal)
Abscess oral (abscess in the mouth)
Dyspnoea (difficult or laboured respiration)
Back pain

50-59:

Fatigue (feeling of tiredness)
Malignant neoplasm progression (cancer tumour came back)
Blood creatinine decreased
Blood pressure decreased
Cystitis (inflammation of the wall of the bladder)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Dyspnoea (difficult or laboured respiration)
Flushing (the warm, red condition of human skin)
Hypovolaemic shock (shock caused by severe blood or fluid loss)
Interstitial lung disease

60+:

Diarrhoea
Fatigue (feeling of tiredness)
Pneumonia
Urinary tract infection
Haematuria (presence of blood in urine)
Muscle spasms (muscle contraction)
Arthralgia (joint pain)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chest discomfort
Decreased appetite

What are the existing conditions these people have? *

Pain: 13 people, 25.00%
Nausea (feeling of having an urge to vomit): 12 people, 23.08%
Constipation: 8 people, 15.38%
Multiple Myeloma (cancer of the plasma cells): 7 people, 13.46%
Neuralgia (pain in one or more nerves): 6 people, 11.54%
Mucosal Inflammation (infection of mucous membrane): 5 people, 9.62%
High Blood Pressure: 5 people, 9.62%
Anaemia (lack of blood): 5 people, 9.62%
Stress And Anxiety: 3 people, 5.77%
Overdose: 3 people, 5.77%

* Approximation only. Some reports may have incomplete information.

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