Naprelan and Premarin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naprelan (naproxen sodium) and Premarin (estrogens, conjugated). Common drug interactions include hypertension among females.

The phase IV clinical study analyzes what interactions people have when they take Naprelan and Premarin. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Naprelan?

Naprelan has active ingredients of naproxen sodium. eHealthMe is studying from 731 Naprelan users. Check the latest studies of Naprelan.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

On Jul, 14, 2026

31 people who take Naprelan and Premarin together, and have interactions are studied.

Naprelan and Premarin drug interactions.

What are the common drug interactions of Naprelan and Premarin, by gender? *:

female:

Hypertension (high blood pressure)
Muscle spasms (muscle contraction)
Dry skin
Impaired healing
Nausea (feeling of having an urge to vomit)
Pruritus (severe itching of the skin)
Rigors (an episode of shaking or exaggerated shivering)
Wound infection
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Blood creatinine increased

male:

n/a

What are the common drug interactions of Naprelan and Premarin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Menometrorrhagia (a condition in which prolonged or excessive uterine bleeding occurs irregularly and more frequently than normal)
Migraine (headache)
Weight increased

30-39:

Chest pain
Depression
Dry skin
Hypertension (high blood pressure)
Injection site reaction
Pain in limb
Localised exfoliation (a peeling off or loss of epidermis at the site of exposure)

40-49:

Muscle spasms (muscle contraction)
Catheter site infection (infection at the site of insertion)
Fall
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Urinary tract infection
Drug dependence
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Impaired healing
Wound infection
Agitation (state of anxiety or nervous excitement)

50-59:

Vomiting
Blood creatinine increased
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Rash
Rigors (an episode of shaking or exaggerated shivering)
Abdominal pain upper
Cardiac failure congestive
Dermatitis lichenoid (lichen simplex chronicus is a chronic inflammation of the skin)
Diarrhoea

60+:

Hypertension (high blood pressure)
Cardiac disorder
Anxiety
Back disorder
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Burning sensation
Cardiac tamponade (fluid accumulates in heart covering)
Cardiomegaly (increased size of heart than normal)
Chest discomfort
Chest pressure sensation (feeling of pressure on chest)

What are the existing conditions these people have? *

Pain: 8 people, 25.81%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 4 people, 12.90%
Muscle Spasms (muscle contraction): 4 people, 12.90%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 12.90%
Gait Disturbance: 4 people, 12.90%
Fatigue (feeling of tiredness): 4 people, 12.90%
Bladder Disorder: 4 people, 12.90%
Sleep Disorder: 3 people, 9.68%
Neuropathy Peripheral (surface nerve damage): 3 people, 9.68%
Metastases To Bone (cancer spreads to bone): 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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