Naprosyn and Ziac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naprosyn (naproxen) and Ziac (bisoprolol fumarate; hydrochlorothiazide). Common drug interactions include cholecystitis chronic among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Naprosyn and Ziac. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Naprosyn?

Naprosyn has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 16,738 Naprosyn users. Check the latest studies of Naprosyn.

What is Ziac?

Ziac has active ingredients of bisoprolol fumarate; hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 4,451 Ziac users. Check the latest studies of Ziac.

On Aug, 02, 2026

30 people who take Naprosyn and Ziac together, and have interactions are studied.

What are the common drug interactions of Naprosyn and Ziac, by gender? *:

female:

Cholecystitis chronic (long lasting infection of gallbladder)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Depression
Pneumonia
Abdominal pain
Acquired oesophageal web (structural abnormalities in the oesophagus)
Altered state of consciousness (altered state of mind)
Anogenital warts
Arrhythmia (irregular heartbeat)
Arthralgia (joint pain)

male:

Anaemia (lack of blood)
Abscess (pus)
Oral infection
Osteomyelitis (infection of bone)
Periodontal disease (disease that attacks the gum and bone and around the teeth)
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously)
Postoperative wound infection
Tinea pedis (a contagious skin infection caused by the ringworm fungus)
Tooth disorder (tooth disease)
Toothache (tooth pain)

What are the common drug interactions of Naprosyn and Ziac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Emotional disorder
Fear
Injury
Cholecystitis chronic (long lasting infection of gallbladder)
Depression
Acute myocardial infarction (acute heart attack)
Blood cholesterol increased
Bone cyst
Bone disorder

40-49:

Urticaria (rash of round, red welts on the skin that itch intensely)

50-59:

Chronic kidney disease
Acute respiratory failure
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Pneumonia
Hypersensitivity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Peripheral vascular disease
Weight increased

60+:

Diarrhoea
Femur fracture
Impaired healing
Oral infection
Osteomyelitis (infection of bone)
Periodontal disease (disease that attacks the gum and bone and around the teeth)
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously)
Postoperative wound infection
Tinea pedis (a contagious skin infection caused by the ringworm fungus)
Tooth disorder (tooth disease)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 11 people, 36.67%
Osteoporosis (bones weak and more likely to break): 10 people, 33.33%
High Blood Cholesterol: 4 people, 13.33%
Hypokalemia (low potassium): 3 people, 10.00%
Fluid Retention (an abnormal accumulation of fluid in the blood): 3 people, 10.00%
Ankylosing Spondylitis (type of arthritis affecting the spine): 3 people, 10.00%
Renal Cell Carcinoma Stage Unspecified (kidney cancer in unknown stage): 2 people, 6.67%
Prostate Infection: 2 people, 6.67%
Insomnia (sleeplessness): 2 people, 6.67%
Birth Control: 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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