Narcan and Dapsone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Narcan (naloxone hydrochloride) and Dapsone (dapsone). Common drug interactions include pain among females and constipation among males.

The phase IV clinical study analyzes what interactions people have when they take Narcan and Dapsone. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Narcan?

Narcan has active ingredients of naloxone hydrochloride. eHealthMe is studying from 3,687 Narcan users. Check the latest studies of Narcan.

What is Dapsone?

Dapsone has active ingredients of dapsone. It is often used in dermatitis herpetiformis. eHealthMe is studying from 11,732 Dapsone users. Check the latest studies of Dapsone.



On Jul, 26, 2026

24 people who take Narcan and Dapsone together, and have interactions are studied.

Narcan and Dapsone drug interactions.

What are the common drug interactions of Narcan and Dapsone, by gender? *:

female:

  1. Pain
  2. Abdominal distension
  3. Breast cancer
  4. Dysphagia (a condition in which swallowing is difficult or painful)
  5. Dyspnoea (difficult or laboured respiration)
  6. Fatigue (feeling of tiredness)
  7. Generalised oedema (swelling all over the body)
  8. Pulmonary embolism (blockage of the main artery of the lung)
  9. Rash
  10. Acute respiratory failure

male:

  1. Constipation
  2. Drug ineffective
  3. Increased appetite
  4. Nephrolithiasis (calculi in the kidneys)
  5. Palpitations (feelings or sensations that your heart is pounding or racing)
  6. Renal failure (kidney dysfunction)
  7. Stiff person syndrome
  8. Atypical pneumonia (acute respiratory disease marked by high fever and coughing)
  9. Chronic kidney disease
  10. Death

What are the common drug interactions of Narcan and Dapsone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Back pain
  2. Cat scratch disease (bacterial infection by cat scratch)
  3. Coma (state of unconsciousness lasting more than six hours)
  4. Constipation
  5. Cyclic vomiting syndrome (prolonged episodes of severe nausea, vomiting)
  6. Drug ineffective
  7. Dyskinesia (abnormality or impairment of voluntary movement)
  8. Hyposmia (impairment of the sense of smell)
  9. Impaired gastric emptying
  10. Increased appetite

30-39:

  1. Abdominal distension
  2. Anaemia of chronic disease
  3. Cataract (clouding of the lens inside the eye)
  4. Chronic graft versus host disease (immune cells attack the host's body cells after transplant)
  5. Depressed mood
  6. Dysphagia (a condition in which swallowing is difficult or painful)
  7. Dyspnoea (difficult or laboured respiration)
  8. Fatigue (feeling of tiredness)
  9. Febrile neutropenia (fever with reduced white blood cells)
  10. Flat affect (absence of emotional response to a situation)

40-49:

  1. Fluid retention (an abnormal accumulation of fluid in the blood)
  2. Generalised oedema (swelling all over the body)
  3. Hepatic lesion
  4. Nephrotic syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema)
  5. Pain
  6. Pulmonary embolism (blockage of the main artery of the lung)
  7. Thrombosis (formation of a blood clot inside a blood vessel)
  8. Anaemia (lack of blood)
  9. Arthralgia (joint pain)
  10. Acute respiratory failure

50-59:

n/a

60+:

  1. Renal failure (kidney dysfunction)
  2. Chronic kidney disease
  3. Death
  4. Liver disorder (liver diseases)
  5. Lung infection

What are the existing conditions these people have? *

  1. Pain: 5 people, 20.83%
  2. Constipation: 5 people, 20.83%
  3. Multiple Myeloma (cancer of the plasma cells): 4 people, 16.67%
  4. Wheezing (a high-pitched whistling sound made while you breath): 3 people, 12.50%
  5. Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 3 people, 12.50%
  6. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 12.50%
  7. High Blood Pressure: 3 people, 12.50%
  8. Cystic Fibrosis (disease of the secretary glands): 3 people, 12.50%
  9. Nausea (feeling of having an urge to vomit): 2 people, 8.33%
  10. Lupus Nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Narcan and Dapsone?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Narcan and Dapsone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Narcan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Dapsone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Narcan and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Dapsone and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on naloxone hydrochloride and dapsone (the active ingredients of Narcan and Dapsone, respectively), and Narcan and Dapsone (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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