Narcan and Romazicon drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Narcan (naloxone hydrochloride) and Romazicon (flumazenil). Common drug interactions include depression among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Narcan and Romazicon. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.

What is Narcan?

Narcan has active ingredients of naloxone hydrochloride. eHealthMe is studying from 3,687 Narcan users. Check the latest studies of Narcan.

What is Romazicon?

Romazicon has active ingredients of flumazenil. eHealthMe is studying from 182 Romazicon users. Check the latest studies of Romazicon.

On Jul, 19, 2026

68 people who take Narcan and Romazicon together, and have interactions are studied.

What are the common drug interactions of Narcan and Romazicon, by gender? *:

female:

Depression
Dizziness
Dysphagia (a condition in which swallowing is difficult or painful)
Osteomyelitis (infection of bone)
Osteopenia (a condition where bone mineral density is lower than normal)
Swelling
Neoplasm malignant (cancer tumour)
Pyrexia (fever)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Back pain

male:

Renal failure (kidney dysfunction)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Chronic kidney disease
Death
Emotional distress
Fall
Pneumonia
Pulmonary oedema (fluid accumulation in the lungs)
Pyrexia (fever)
Bradycardia (abnormally slow heart action)

What are the common drug interactions of Narcan and Romazicon, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Muscle twitching

30-39:

Agitation (state of anxiety or nervous excitement)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Coma (state of unconsciousness lasting more than six hours)
Pain
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)
Abdominal discomfort
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depression
Diarrhoea
Drug dependence

40-49:

Abdominal pain
Fatigue (feeling of tiredness)
Abdominal distension
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Hemiparesis (weakness on one side of the body)
Locked-in syndrome (a condition in which a patient is aware and awake but cannot move or communicate verbally due to complete paralysis)
Pyrexia (fever)
Respiratory distress (difficulty in breathing)
Respiratory failure (inadequate gas exchange by the respiratory system)
Depression

50-59:

Neoplasm malignant (cancer tumour)
Osteomyelitis (infection of bone)
Hypertension (high blood pressure)
Swelling
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Back pain
Bone disorder
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Constipation
Depression

60+:

Renal failure (kidney dysfunction)
Hypotension (abnormally low blood pressure)
Anxiety
Bradycardia (abnormally slow heart action)
Cardiac arrest
Chronic kidney disease
Fall
Fear
Pneumonia
Pyrexia (fever)

What are the existing conditions these people have? *

Pain: 15 people, 22.06%
Lung Cancer - Non-Small Cell (lung cancer): 12 people, 17.65%
Hypercalcaemia Of Malignancy (elevated calcium (ca+) level in the blood with cancer): 12 people, 17.65%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 11.76%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 6 people, 8.82%
Depression: 5 people, 7.35%
Multiple Myeloma (cancer of the plasma cells): 4 people, 5.88%
High Blood Pressure: 4 people, 5.88%
Breast Cancer: 4 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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