Nattokinase and Biotin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nattokinase (nattokinase) and Biotin (biotin). Common drug interactions include open wound among females and gastrointestinal infection among males.

The phase IV clinical study analyzes what interactions people have when they take Nattokinase and Biotin. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Nattokinase?

Nattokinase has active ingredients of nattokinase. It is often used in blood clots. eHealthMe is studying from 227 Nattokinase users. Check the latest studies of Nattokinase.

What is Biotin?

Biotin has active ingredients of biotin. It is often used in hair loss. eHealthMe is studying from 35,393 Biotin users. Check the latest studies of Biotin.

On Jul, 20, 2026

16 people who take Nattokinase and Biotin together, and have interactions are studied.

Nattokinase and Biotin drug interactions.

What are the common drug interactions of Nattokinase and Biotin, by gender? *:

female:

Open wound
Pain in extremity
Skin exfoliation (removal of the oldest dead skin cells)
Skin fragility (trauma-induced blisters and erosions of skin)
Application site pruritus (application site severe itching of the skin)
Application site rash
Arthralgia (joint pain)
Back pain
Blood glucose increased
Blood sodium decreased

male:

Gastrointestinal infection (infection of stomach and intestine)
Lyme disease (a bacterial infection that is spread to humans by infected ticks)

What are the common drug interactions of Nattokinase and Biotin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Application site pruritus (application site severe itching of the skin)
Application site rash
Headache (pain in head)
Hypersensitivity
Peripheral swelling

60+:

Acute sinusitis
Colitis (inflammation of colon)
Blood glucose increased
Blood sodium decreased
Confusional state
Drug ineffective
Emotional disorder
Fatigue (feeling of tiredness)
Urticaria (rash of round, red welts on the skin that itch intensely)
Uterine pain

What are the existing conditions these people have? *

Sleep Disorder: 4 people, 25.00%
Hyperglycemia (high blood sugar): 2 people, 12.50%
Cushing's Syndrome (obesity, a rounded face, increased fat): 2 people, 12.50%
Osteopenia (a condition where bone mineral density is lower than normal): 2 people, 12.50%
Uterine Pain: 1 person, 6.25%
Blood Pressure Abnormal: 1 person, 6.25%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 1 person, 6.25%
Drug Intolerance (drug sensitivity): 1 person, 6.25%
Headache (pain in head): 1 person, 6.25%
Menopause (end of monthly cycles in women): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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