Neurontin and Methylphenidate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Neurontin (gabapentin) and Methylphenidate (methylphenidate). Common drug interactions include eosinophil count increased among females and suicidal ideation among males.

The phase IV clinical study analyzes what interactions people have when they take Neurontin and Methylphenidate. It is created by eHealthMe based on reports of 74 people who take the same drugs from the FDA, and is updated regularly.

What is Neurontin?

Neurontin has active ingredients of gabapentin. It is often used in neuralgia. eHealthMe is studying from 107,468 Neurontin users. Check the latest studies of Neurontin.

What is Methylphenidate?

Methylphenidate has active ingredients of methylphenidate. eHealthMe is studying from 8,216 Methylphenidate users. Check the latest studies of Methylphenidate.

On Jul, 09, 2026

74 people who take Neurontin and Methylphenidate together, and have interactions are studied.

Neurontin and Methylphenidate drug interactions.

What are the common drug interactions of Neurontin and Methylphenidate, by gender? *:

female:

Eosinophil count increased
Eye disorder
Fluid retention (an abnormal accumulation of fluid in the blood)
Foot fracture
Gastric polyps (abnormal growth of stomach tissue projecting from a mucous membrane)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Glaucoma (increased fluid pressure in the eye with vision loss)
Haematocrit increased
Head injury
Hypertension (high blood pressure)

male:

Suicidal ideation
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Surgery
Weight increased
Diarrhoea
Generalised anxiety disorder (excessive, uncontrollable, unexplained and often irrational worry)
Abnormal sleep-related event
Anxiety
Bone density decreased
Cataplexy (loss of muscle tone accompanied by full conscious awareness)

What are the common drug interactions of Neurontin and Methylphenidate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Cerebral haemorrhage (bleeding within the brain)
Headache (pain in head)
Hypersomnia (excessive daytime sleepiness (eds))
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Pyrexia (fever)
Vomiting

20-29:

n/a

30-39:

Depression
Generalised anxiety disorder (excessive, uncontrollable, unexplained and often irrational worry)
Suicidal ideation
Bone density decreased
Cough
Dyspnoea (difficult or laboured respiration)
Emotional distress
Fatigue (feeling of tiredness)
Foot fracture
Hand fracture

40-49:

Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Surgery

50-59:

Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Adrenal adenoma (benign tumour of the glandular type (adenoma) in the adrenal gland)
Adrenal cyst (cysts of the adrenal gland)
Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Depression
Drug hypersensitivity
Expanded disability status scale score increased
Fall
Hospitalisation
Kidney infection

60+:

Dizziness
Diarrhoea
Blood phosphorus decreased
Blood thyroid stimulating hormone decreased
Blood thyroid stimulating hormone increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cough
Dry mouth
Erythema (redness of the skin)
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 44 people, 59.46%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 35 people, 47.30%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 12 people, 16.22%
Pain: 5 people, 6.76%
Drowsiness: 5 people, 6.76%

* Approximation only. Some reports may have incomplete information.

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