Nexium and Dimeticone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nexium (esomeprazole magnesium) and Dimeticone (simethicone). Common drug interactions include hypovitaminosis among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Nexium and Dimeticone. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Nexium?

Nexium has active ingredients of esomeprazole magnesium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 245,678 Nexium users. Check the latest studies of Nexium.

What is Dimeticone?

Dimeticone has active ingredients of simethicone. eHealthMe is studying from 764 Dimeticone users. Check the latest studies of Dimeticone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

29 people who take Nexium and Dimeticone together, and have interactions are studied.

Nexium and Dimeticone drug interactions.

What are the common drug interactions of Nexium and Dimeticone, by gender? *:

female:

Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins)
Influenza
Intestinal obstruction
Limb injury
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscle spasms (muscle contraction)
Muscular weakness (muscle weakness)
Myasthenia gravis (a chronic condition that causes muscles to tire and weaken easily)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nephrolithiasis (calculi in the kidneys)

male:

Chronic kidney disease
Renal disorder (kidney disease)
Blood glucose increased
Gastric haemorrhage (bleeding stomach)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Abdominal distension
Anaemia (lack of blood)
Ascites (accumulation of fluid in the abdominal cavity)
Cardiac failure

What are the common drug interactions of Nexium and Dimeticone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anaemia (lack of blood)
Ascites (accumulation of fluid in the abdominal cavity)
Cardiac failure
Haematocrit decreased
Haemoglobin decreased
Red blood cell count decreased

30-39:

Headache (pain in head)
Hypertension (high blood pressure)
Iron deficiency anaemia
Nasopharyngitis (inflammation of the nasopharynx)
Oedema (fluid collection in tissue)
Premenstrual syndrome
Vulvovaginal candidiasis (vulvovaginal infection by fungi)
Gastroenteritis (inflammation of stomach and intestine)
Nausea (feeling of having an urge to vomit)
Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)

40-49:

Abdominal adhesions (inflammation of abdomen)
Drug ineffective
Drug intolerance (drug sensitivity)
Intestinal obstruction
Myasthenia gravis (a chronic condition that causes muscles to tire and weaken easily)

50-59:

Back injury
Coccydynia (pain in the coccyx or tailbone area)
Fall
Osteoporosis (bones weak and more likely to break)
Road traffic accident
Spinal column injury (spinal cord bone injury)
Weight increased

60+:

Chronic kidney disease
Renal disorder (kidney disease)
Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Sinus arrest (sinus pause)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Subcutaneous haematoma (collection of blood outside the blood vessels on the skin)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)

What are the existing conditions these people have? *

High Blood Pressure: 5 people, 17.24%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 10.34%
Nephrogenic Anaemia (anaemia due to kidney disease): 3 people, 10.34%
High Blood Cholesterol: 3 people, 10.34%
Constipation: 2 people, 6.90%
Diabetes: 2 people, 6.90%
Extrapyramidal Disorder (involuntary muscle spasms in the face and neck): 2 people, 6.90%
Fluid Retention (an abnormal accumulation of fluid in the blood): 2 people, 6.90%
Gastritis (inflammation of stomach): 2 people, 6.90%
Stomach Discomfort (pain in abdomen): 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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