Nexium and Ilevro drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nexium (esomeprazole magnesium) and Ilevro (nepafenac). Common drug interactions include tubulointerstitial nephritis among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Nexium and Ilevro. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Nexium?

Nexium has active ingredients of esomeprazole magnesium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 245,678 Nexium users. Check the latest studies of Nexium.

What is Ilevro?

Ilevro has active ingredients of nepafenac. eHealthMe is studying from 1,531 Ilevro users. Check the latest studies of Ilevro.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

39 people who take Nexium and Ilevro together, and have interactions are studied.

What are the common drug interactions of Nexium and Ilevro, by gender? *:

female:

Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Nephrogenic anaemia (anaemia due to kidney disease)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Renal ischaemia (lack of blood supply to kidney)
Renal tubular necrosis (death of kidney tubules)
Anxiety
Depression
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Dysphagia (a condition in which swallowing is difficult or painful)
Failure to thrive (inadequate weight gain and physical growth in children)

male:

Chronic kidney disease
Renal cyst (kidney cyst)
Nephrogenic anaemia (anaemia due to kidney disease)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Renal failure (kidney dysfunction)
Renal haemangioma (kidney tumour filled with blood)
Cataract (clouding of the lens inside the eye)

What are the common drug interactions of Nexium and Ilevro, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Decreased activity
Depression
Emotional distress
Pain
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Renal ischaemia (lack of blood supply to kidney)
Renal tubular necrosis (death of kidney tubules)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Dysphagia (a condition in which swallowing is difficult or painful)
Failure to thrive (inadequate weight gain and physical growth in children)
Oesophageal injury
Oesophageal stenosis (narrowing of oesophagus)
Renal pain (kidney pain)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Renal haemangioma (kidney tumour filled with blood)
Alopecia (absence of hair from areas of the body)

What are the existing conditions these people have? *

Pain: 15 people, 38.46%
High Blood Cholesterol: 14 people, 35.90%
High Blood Pressure: 10 people, 25.64%
Diabetes: 10 people, 25.64%
Infection: 9 people, 23.08%
Stress And Anxiety: 9 people, 23.08%
Blood Pressure Abnormal: 9 people, 23.08%
Inflammation: 7 people, 17.95%
Headache (pain in head): 7 people, 17.95%
Gastric Ulcer (stomach ulcer): 7 people, 17.95%

* Approximation only. Some reports may have incomplete information.

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