Nexium and Odefsey drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nexium (esomeprazole magnesium) and Odefsey (emtricitabine; rilpivirine hydrochloride; tenofovir alafenamide fumarate). Common drug interactions include anhedonia among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Nexium and Odefsey. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Nexium?

Nexium has active ingredients of esomeprazole magnesium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 245,677 Nexium users. Check the latest studies of Nexium.

What is Odefsey?

Odefsey has active ingredients of emtricitabine; rilpivirine hydrochloride; tenofovir alafenamide fumarate. It is often used in hiv infection. eHealthMe is studying from 4,605 Odefsey users. Check the latest studies of Odefsey.

On Jul, 14, 2026

21 people who take Nexium and Odefsey together, and have interactions are studied.

What are the common drug interactions of Nexium and Odefsey, by gender? *:

female:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Osteoporosis (bones weak and more likely to break)
Multiple fractures
Osteopenia (a condition where bone mineral density is lower than normal)
Bone density decreased
Bone loss
Depression

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Fatigue (feeling of tiredness)
Nephropathy (damage to or disease of a kidney)
Blood creatinine increased
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Foot fracture
Hip arthroplasty
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)

What are the common drug interactions of Nexium and Odefsey, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Oesophageal candidiasis (fungal infection of oesophagus)

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Bone density decreased
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Chronic kidney disease
Hip arthroplasty
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Chronic kidney disease
Depression
Bone density decreased
Nephropathy (damage to or disease of a kidney)
Renal impairment (severely reduced kidney function)
Asthenia (weakness)

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Headache (pain in head)
Immune thrombocytopenic purpura (destruction of blood platelets due to the presence of antiplatelet auto antibodies)
Malaise (a feeling of general discomfort or uneasiness)
Neck pain
Pain in extremity
Renal disorder (kidney disease)

What are the existing conditions these people have? *

Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 4 people, 19.05%
Depression: 4 people, 19.05%
Bacterial Infection: 4 people, 19.05%
Inflammation: 3 people, 14.29%
Gastric Ulcer (stomach ulcer): 3 people, 14.29%
Stress And Anxiety: 2 people, 9.52%
Sleep Apnea Syndrome: 2 people, 9.52%
Pain: 2 people, 9.52%
Erection Problems: 2 people, 9.52%
Androgen Deficiency: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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