Nexium and Synalar drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nexium (esomeprazole magnesium) and Synalar (fluocinolone acetonide). Common drug interactions include chronic kidney disease among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Nexium and Synalar. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Nexium?

Nexium has active ingredients of esomeprazole magnesium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 245,678 Nexium users. Check the latest studies of Nexium.

What is Synalar?

Synalar has active ingredients of fluocinolone acetonide. eHealthMe is studying from 332 Synalar users. Check the latest studies of Synalar.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

12 people who take Nexium and Synalar together, and have interactions are studied.

What are the common drug interactions of Nexium and Synalar, by gender? *:

female:

Chronic kidney disease
Femur fracture
Migraine (headache)
Osteoporosis (bones weak and more likely to break)
Pain
Type 1 diabetes mellitus
Vitamin d deficiency
Arthralgia (joint pain)
Cardiac failure congestive
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

male:

Drug ineffective

What are the common drug interactions of Nexium and Synalar, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cardiac disorder
Migraine (headache)
Type 1 diabetes mellitus
Cardiac failure congestive
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Joint injury
Thrombosis (formation of a blood clot inside a blood vessel)
Viral cardiomyopathy (weakness in the muscle of the heart due to viral infection)

30-39:

n/a

40-49:

Chronic kidney disease

50-59:

Pain
Vitamin d deficiency
Arthralgia (joint pain)
Headache (pain in head)
Insomnia (sleeplessness)
Nephrogenic fibrosing dermopathy (involves fibrosis of skin, joints, eyes due to kidney disease)
Vision blurred
Visual acuity reduced (reduced clearness of vision)
Osteonecrosis (death of bone)
Anxiety

60+:

Drug ineffective
Small intestinal haemorrhage (bleeding from small intestine)

What are the existing conditions these people have? *

Hiv Infection: 2 people, 16.67%
Post-Traumatic Stress Disorder: 2 people, 16.67%
Osteoporosis (bones weak and more likely to break): 2 people, 16.67%
High Blood Pressure: 1 person, 8.33%
Asthma: 1 person, 8.33%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 8.33%
Cardiomyopathy (weakening of the heart muscle): 1 person, 8.33%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 1 person, 8.33%
Gouty Arthritis (joint inflammation with crystal formation): 1 person, 8.33%
Hair Loss: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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