Nexium and Tylox drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nexium (esomeprazole magnesium) and Tylox (acetaminophen; oxycodone hydrochloride). Common drug interactions include renal failure among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Nexium and Tylox. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Nexium?

Nexium has active ingredients of esomeprazole magnesium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 245,678 Nexium users. Check the latest studies of Nexium.

What is Tylox?

Tylox has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 369 Tylox users. Check the latest studies of Tylox.

On Aug, 05, 2026

16 people who take Nexium and Tylox together, and have interactions are studied.

What are the common drug interactions of Nexium and Tylox, by gender? *:

female:

Renal failure (kidney dysfunction)
Death
Renal injury (kidney injury)
Chronic kidney disease
Drug ineffective
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Adverse drug reaction
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Dyspnoea (difficult or laboured respiration)

male:

Renal failure (kidney dysfunction)
Chronic kidney disease
Arthralgia (joint pain)
Asthenia (weakness)
Atrioventricular block first degree (heart block first degree)
Back pain
Blood bicarbonate decreased
Blood cholesterol increased
Blood glucose increased
Blood pressure increased

What are the common drug interactions of Nexium and Tylox, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Death
Renal failure (kidney dysfunction)
Renal injury (kidney injury)

50-59:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Abdominal pain upper
Aphagia (inability or refusal to swallow)
Blood cholesterol increased
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Decreased appetite

60+:

Blood glucose increased
Dehydration (dryness resulting from the removal of water)
Blood pressure increased
Blood sodium decreased
Blood uric acid increased
Carbon dioxide decreased
Drug hypersensitivity
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Dysstasia (difficulty in standing)

What are the existing conditions these people have? *

High Blood Cholesterol: 7 people, 43.75%
High Blood Pressure: 4 people, 25.00%
Diabetes: 3 people, 18.75%
Stress And Anxiety: 2 people, 12.50%
Fluid Retention (an abnormal accumulation of fluid in the blood): 2 people, 12.50%
Insomnia (sleeplessness): 2 people, 12.50%
Tremor (trembling or shaking movements in one or more parts of your body): 1 person, 6.25%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 6.25%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 6.25%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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