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Nexletol and Metformin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nexletol (bempedoic acid) and Metformin (metformin hydrochloride). Common drug interactions include asthenia among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Nexletol and Metformin. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Nexletol?

Nexletol has active ingredients of bempedoic acid. eHealthMe is studying from 550 Nexletol users. Check the latest studies of Nexletol.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

On Jul, 14, 2026

16 people who take Nexletol and Metformin together, and have interactions are studied.

Nexletol and Metformin drug interactions.

What are the common drug interactions of Nexletol and Metformin, by gender? *:

female:

  1. Asthenia (weakness)
  2. Fatigue (feeling of tiredness)
  3. Arthralgia (joint pain)
  4. Muscle spasms (muscle contraction)
  5. Myalgia (muscle pain)
  6. Abdominal discomfort
  7. Blepharospasm (any abnormal contraction or twitch of the eyelid)
  8. Breast cancer
  9. Colitis (inflammation of colon)
  10. Disturbance in attention

male:

  1. Arthralgia (joint pain)
  2. Rash
  3. Weight decreased
  4. Abdominal pain upper
  5. Asthenia (weakness)
  6. Death
  7. Fatigue (feeling of tiredness)
  8. Hypotension (abnormally low blood pressure)
  9. Induration (thickening of tissue)
  10. Pain in extremity

What are the common drug interactions of Nexletol and Metformin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Arthralgia (joint pain)
  2. Asthenia (weakness)
  3. Disturbance in attention
  4. Dizziness
  5. Fall
  6. Gastric polyps (abnormal growth of stomach tissue projecting from a mucous membrane)
  7. Gastritis (inflammation of stomach)
  8. Gastrointestinal infection (infection of stomach and intestine)
  9. Haemoglobin decreased
  10. Haemorrhage (bleeding)

What are the existing conditions these people have? *

  1. High Blood Cholesterol: 6 people, 37.50%
  2. Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 18.75%
  3. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 12.50%
  4. High Blood Pressure: 2 people, 12.50%
  5. Type 2 Diabetes: 1 person, 6.25%
  6. Parkinson's Disease: 1 person, 6.25%
  7. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 6.25%
  8. Low Density Lipoprotein Increased (cholesterol increased in blood): 1 person, 6.25%
  9. Low Density Lipoprotein Abnormal (cholesterol abnormal): 1 person, 6.25%
  10. Immunodeficiency Common Variable: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Nexletol and Metformin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Nexletol and Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Nexletol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Nexletol and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Metformin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on bempedoic acid and metformin hydrochloride (the active ingredients of Nexletol and Metformin, respectively), and Nexletol and Metformin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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