Nexplanon and Excedrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nexplanon (etonogestrel) and Excedrin (acetaminophen; aspirin; caffeine). Common drug interactions include dizziness among females.

The phase IV clinical study analyzes what interactions people have when they take Nexplanon and Excedrin. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Nexplanon?

Nexplanon has active ingredients of etonogestrel. It is often used in birth control. eHealthMe is studying from 46,431 Nexplanon users. Check the latest studies of Nexplanon.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

49 people who take Nexplanon and Excedrin together, and have interactions are studied.

Nexplanon and Excedrin drug interactions.

What are the common drug interactions of Nexplanon and Excedrin, by gender? *:

female:

Dizziness
Fatigue (feeling of tiredness)
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins)
Mineral deficiency (lack of mineral)
Muscle spasms (muscle contraction)
Psoriasis (immune-mediated disease that affects the skin)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Abdominal pain
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Diarrhoea

male:

n/a

What are the common drug interactions of Nexplanon and Excedrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain upper
Adnexa uteri pain
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Skin infection
Vomiting

20-29:

Rash
Psoriasis (immune-mediated disease that affects the skin)
Dizziness
Anxiety
Breast pain
Dysmenorrhoea (painful menstruation)
Hypoaesthesia (reduced sense of touch or sensation)
Muscle spasms (muscle contraction)
Chills (felling of cold)
Diarrhoea

30-39:

Depression
Abortion spontaneous (naturally occurring miscarriage)
Abdominal pain
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Disease recurrence
Vaginal haemorrhage (vaginal bleeding)
Affective disorder (mental disorder)
Anaphylactic reaction (serious allergic reaction)
Anxiety
Appetite disorder (abnormal eating habits)

40-49:

Diarrhoea
Drug ineffective
Dysphagia (a condition in which swallowing is difficult or painful)
Eye pain
Fatigue (feeling of tiredness)
Laryngitis (inflammation of the larynx)
Memory impairment
Metrorrhagia (uterine bleeding at irregular intervals)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

50-59:

Dizziness
Ear infection
Myalgia (muscle pain)
Pyrexia (fever)
Sinusitis (inflammation of sinus)
Urinary tract infection

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 20 people, 40.82%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 22.45%
Psoriasis (immune-mediated disease that affects the skin): 3 people, 6.12%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 6.12%
Migraine (headache): 3 people, 6.12%
Feeling Abnormal: 3 people, 6.12%

* Approximation only. Some reports may have incomplete information.

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