Nexplanon and Protonix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nexplanon (etonogestrel) and Protonix (pantoprazole sodium). Common drug interactions include implant site pain among females.

The phase IV clinical study analyzes what interactions people have when they take Nexplanon and Protonix. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Nexplanon?

Nexplanon has active ingredients of etonogestrel. It is often used in birth control. eHealthMe is studying from 46,431 Nexplanon users. Check the latest studies of Nexplanon.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,658 Protonix users. Check the latest studies of Protonix.

On Jul, 16, 2026

50 people who take Nexplanon and Protonix together, and have interactions are studied.

Nexplanon and Protonix drug interactions.

What are the common drug interactions of Nexplanon and Protonix, by gender? *:

female:

Implant site pain
Headache (pain in head)
Migraine (headache)
Pain
Pain in extremity
Weight increased
Discomfort
Anxiety
Back pain
Cat scratch disease (bacterial infection by cat scratch)

male:

n/a

What are the common drug interactions of Nexplanon and Protonix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Pancreatic enlargement
Splenomegaly (enlargement of spleen)
Vomiting

20-29:

Discomfort
Cat scratch disease (bacterial infection by cat scratch)
Dizziness
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Implant site pain
Complication of device insertion
Hypoaesthesia (reduced sense of touch or sensation)
Abdominal discomfort
Abdominal pain upper
Acute pulmonary histoplasmosis (acute infection by inhalation of spores of the fungus histoplasma capsulatum)

30-39:

Device expulsion
Implant site extravasation
Weight increased
Application site discomfort
Implant site irritation
Implant site pain

40-49:

Complication of device insertion
Gastric bypass
Procedural haemorrhage (procedural bleeding)
Weight decreased
Anxiety
Bone pain
Breast mass
Breast pain
Haemorrhage (bleeding)
Hot flush (sudden feelings of heat)

50-59:

Asthenia (weakness)
Fatigue (feeling of tiredness)
Fall
Fungal oesophagitis (fungal inflammation of the oesophagus)
Influenza like illness
Neck pain
Pain in extremity
Restless legs syndrome (a powerful urge to move your legs)
Retching (strong involuntary effort to vomit)
Visual impairment

60+:

n/a

What are the existing conditions these people have? *

Stress And Anxiety: 7 people, 14.00%
Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 7 people, 14.00%
Pain: 3 people, 6.00%
Immunodeficiency Common Variable: 3 people, 6.00%
Hypersensitivity: 3 people, 6.00%

* Approximation only. Some reports may have incomplete information.

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