Niacin and Oxycontin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Niacin (niacin) and Oxycontin (oxycodone hydrochloride). Common drug interactions include cough among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Niacin and Oxycontin. It is created by eHealthMe based on reports of 77 people who take the same drugs from the FDA, and is updated regularly.

What is Niacin?

Niacin has active ingredients of niacin. It is often used in high blood cholesterol. eHealthMe is studying from 9,009 Niacin users. Check the latest studies of Niacin.

What is Oxycontin?

Oxycontin has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 212,533 Oxycontin users. Check the latest studies of Oxycontin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

77 people who take Niacin and Oxycontin together, and have interactions are studied.

What are the common drug interactions of Niacin and Oxycontin, by gender? *:

female:

Cough
Dehydration (dryness resulting from the removal of water)
Disease progression
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Pneumonia
Vomiting
Abdominal discomfort
Abdominal pain
Abdominal wall abscess (abdominal wall infection)

male:

Anxiety
Injury
Vomiting
Bone pain
Infection
Diarrhoea
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Headache (pain in head)

What are the common drug interactions of Niacin and Oxycontin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Affective disorder (mental disorder)
Agitation (state of anxiety or nervous excitement)
Anxiety
Asthenia (weakness)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug abuse
Drug dependence
Hyperglycaemia (high blood sugar)
Hyperlipidaemia (presence of excess lipids in the blood)

30-39:

Eye infection
Infection
Psoriasis (immune-mediated disease that affects the skin)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Respiratory tract infection
Synovial cyst (cyst of joint filled with synovial fluid)
Vaginal infection

40-49:

Agitation (state of anxiety or nervous excitement)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug dependence
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Oedema peripheral (superficial swelling)
Somnolence (a state of near-sleep, a strong desire for sleep)
Abdominal pain
Anxiety

50-59:

Injury
Cellulitis (infection under the skin)
Haematuria (presence of blood in urine)
Osteonecrosis of jaw (death of bone of jaw)
Osteoporosis (bones weak and more likely to break)
Anaemia (lack of blood)
Metastases to bone (cancer spreads to bone)
Pleural effusion (water on the lungs)
Scar
Gait disturbance

60+:

Infection
Anxiety
Haematochezia (passage of stools containing blood)
Haematocrit decreased
Haemoglobin decreased
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Oral pain
Pneumonia
Arrhythmia (irregular heartbeat)
Bone disorder

What are the existing conditions these people have? *

Arthritis (form of joint disorder that involves inflammation of one or more joints): 14 people, 18.18%
Metastases To Bone (cancer spreads to bone): 10 people, 12.99%
High Blood Pressure: 6 people, 7.79%
Diabetes: 6 people, 7.79%
Depression: 5 people, 6.49%
Bipolar Disorder (mood disorder): 5 people, 6.49%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 5.19%

* Approximation only. Some reports may have incomplete information.

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