Nicorette and Glucotrol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nicorette (nicotine polacrilex) and Glucotrol (glipizide). Common drug interactions include abdominal pain among females and drug dependence among males.

The phase IV clinical study analyzes what interactions people have when they take Nicorette and Glucotrol. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Nicorette?

Nicorette has active ingredients of nicotine polacrilex. It is often used in quit smoking. eHealthMe is studying from 18,484 Nicorette users. Check the latest studies of Nicorette.

What is Glucotrol?

Glucotrol has active ingredients of glipizide. It is often used in diabetes. eHealthMe is studying from 20,322 Glucotrol users. Check the latest studies of Glucotrol.



On Aug, 02, 2026

11 people who take Nicorette and Glucotrol together, and have interactions are studied.

Nicorette and Glucotrol drug interactions.

What are the common drug interactions of Nicorette and Glucotrol, by gender? *:

female:

  1. Abdominal pain
  2. Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
  3. Chronic respiratory failure
  4. Colitis (inflammation of colon)
  5. Dehydration (dryness resulting from the removal of water)
  6. Depression
  7. Diarrhoea
  8. Disease progression
  9. Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
  10. Dizziness

male:

  1. Drug dependence

What are the common drug interactions of Nicorette and Glucotrol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Bone disorder
  2. Bone erosion
  3. Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
  4. Chronic respiratory failure
  5. Colitis (inflammation of colon)
  6. Dehydration (dryness resulting from the removal of water)
  7. Depression
  8. Diarrhoea
  9. Disease progression
  10. Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)

60+:

  1. Catheter site cellulitis (infection of cells near catheter)
  2. Drug dependence
  3. Infection

What are the existing conditions these people have? *

  1. Pain: 4 people, 36.36%
  2. Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 3 people, 27.27%
  3. Psoriasis (immune-mediated disease that affects the skin): 2 people, 18.18%
  4. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 18.18%
  5. Multiple Myeloma (cancer of the plasma cells): 2 people, 18.18%
  6. Fluid Retention (an abnormal accumulation of fluid in the blood): 2 people, 18.18%
  7. Dry Eyes (lack of adequate tears): 2 people, 18.18%
  8. Diarrhea: 2 people, 18.18%
  9. Neuropathy Peripheral (surface nerve damage): 1 person, 9.09%
  10. Depression: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Nicorette and Glucotrol?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Nicorette and Glucotrol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Nicorette:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Glucotrol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Nicorette and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Glucotrol and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on nicotine polacrilex and glipizide (the active ingredients of Nicorette and Glucotrol, respectively), and Nicorette and Glucotrol (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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