Nicotine and Hyzaar drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nicotine (nicotine) and Hyzaar (hydrochlorothiazide; losartan potassium). Common drug interactions include vascular pseudoaneurysm among females and altered state of consciousness among males.

The phase IV clinical study analyzes what interactions people have when they take Nicotine and Hyzaar. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Nicotine?

Nicotine has active ingredients of nicotine. It is often used in quit smoking. eHealthMe is studying from 20,443 Nicotine users. Check the latest studies of Nicotine.

What is Hyzaar?

Hyzaar has active ingredients of hydrochlorothiazide; losartan potassium. It is often used in high blood pressure. eHealthMe is studying from 16,614 Hyzaar users. Check the latest studies of Hyzaar.

On Jul, 12, 2026

11 people who take Nicotine and Hyzaar together, and have interactions are studied.

What are the common drug interactions of Nicotine and Hyzaar, by gender? *:

female:

Vascular pseudoaneurysm (leakage of arterial blood from an artery into the surrounding tissue with a continuing communication between the originating artery and the resultant adjacent cavity)
Ventricular hypokinesia (muscle of one's heart does not contract as much as most peoples' hearts do)
Vomiting
Abdominal discomfort
Abdominal pain upper
Activities of daily living impaired
Adrenal adenoma (benign tumour of the glandular type (adenoma) in the adrenal gland)
Adrenal mass
Anastomotic stenosis
Anastomotic ulcer

male:

Altered state of consciousness (altered state of mind)
Abdominal pain lower
Back pain
Benign prostatic hyperplasia (benign enlargement of the prostate)
Bladder obstruction
Blood pressure decreased
Blood pressure fluctuation
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac failure congestive
Cardiac murmur (an heart sound in valve abnormality)

What are the common drug interactions of Nicotine and Hyzaar, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Altered state of consciousness (altered state of mind)
Cerebral atrophy (decrement in size of brain)
Chronic kidney disease
Hemiparesis (weakness on one side of the body)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

50-59:

Hypoaesthesia (reduced sense of touch or sensation)
Hypokinesia (decreased bodily movement)
Ischaemic cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Thrombosis (formation of a blood clot inside a blood vessel)
Vascular pseudoaneurysm (leakage of arterial blood from an artery into the surrounding tissue with a continuing communication between the originating artery and the resultant adjacent cavity)
Ventricular hypokinesia (muscle of one's heart does not contract as much as most peoples' hearts do)
Angioedema (rapid swelling of the dermis)
Asthenia (weakness)
Coronary artery stenosis (narrowing of coronary artery)

60+:

Abdominal discomfort
Abdominal pain upper
Asthenia (weakness)
Back pain
Balance disorder
Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Bone neoplasm (tumour of bone)
Bone pain
Candidiasis (candidiasis or thrush is a fungal infection)

What are the existing conditions these people have? *

Infection: 4 people, 36.36%
Hiv Infection: 4 people, 36.36%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 27.27%
Pain: 2 people, 18.18%
Percutaneous Coronary Intervention: 2 people, 18.18%
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins): 1 person, 9.09%
High Blood Cholesterol: 1 person, 9.09%
Herpes Zoster: 1 person, 9.09%
Heart Attack: 1 person, 9.09%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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