Nicotine and Keytruda drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nicotine (nicotine) and Keytruda (pembrolizumab). Common drug interactions include cough among females and hereditary angioedema among males.

The phase IV clinical study analyzes what interactions people have when they take Nicotine and Keytruda. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Nicotine?

Nicotine has active ingredients of nicotine. It is often used in quit smoking. eHealthMe is studying from 20,443 Nicotine users. Check the latest studies of Nicotine.

What is Keytruda?

Keytruda has active ingredients of pembrolizumab. It is often used in renal cell carcinoma. eHealthMe is studying from 57,404 Keytruda users. Check the latest studies of Keytruda.

On Jul, 11, 2026

13 people who take Nicotine and Keytruda together, and have interactions are studied.

Nicotine and Keytruda drug interactions.

What are the common drug interactions of Nicotine and Keytruda, by gender? *:

female:

Cough
Headache (pain in head)
Myositis (inflammation of the muscles)
Odynophagia (painful swallowing, in the mouth (oropharynx) or oesophagus)
Pruritus (severe itching of the skin)
Pyrexia (fever)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)

male:

Hereditary angioedema (recurrent episodes of severe swelling)
Injection site discharge
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Nausea (feeling of having an urge to vomit)
Pneumonia
Respiratory failure (inadequate gas exchange by the respiratory system)
Type 1 diabetes mellitus
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Colitis (inflammation of colon)
Thrombocytopenia (decrease of platelets in blood)

What are the common drug interactions of Nicotine and Keytruda, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Pleural effusion (water on the lungs)

50-59:

Colitis (inflammation of colon)
Thrombocytopenia (decrease of platelets in blood)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Failure to thrive (inadequate weight gain and physical growth in children)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Nausea (feeling of having an urge to vomit)

60+:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Autoimmune pancreatitis (autoimmune pancreatitis (aip) is an increasingly recognized type of chronic pancreatitis)
Pyrexia (fever)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Respiratory failure (inadequate gas exchange by the respiratory system)
Type 1 diabetes mellitus
Cough
Death
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Headache (pain in head)

What are the existing conditions these people have? *

Hereditary Angioedema (recurrent episodes of severe swelling): 3 people, 23.08%
Non-Small Cell Lung Cancer Metastatic (type of epithelial lung cancer spreads to other parts): 1 person, 7.69%
Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 1 person, 7.69%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 1 person, 7.69%
Lung Squamous Cell Carcinoma Stage Iv (the lung cancer has spread to the other lung, and/or to lymph nodes, fluid around the lungs or heart, and/or other places in the body, such as the brain, liver, adrenal glands, kidneys, or bones): 1 person, 7.69%
Lung Neoplasm Malignant (cancer tumour of lung): 1 person, 7.69%
Lung Cancer Metastatic (lung cancer spreads to other parts): 1 person, 7.69%
Lung Cancer - Non-Small Cell (lung cancer): 1 person, 7.69%
Immune System Disorder: 1 person, 7.69%
Gait Disturbance: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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