Nicotine and Librium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nicotine (nicotine) and Librium (chlordiazepoxide hydrochloride). Common drug interactions include drug ineffective among females and face oedema among males.

The phase IV clinical study analyzes what interactions people have when they take Nicotine and Librium. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Nicotine?

Nicotine has active ingredients of nicotine. It is often used in quit smoking. eHealthMe is studying from 20,443 Nicotine users. Check the latest studies of Nicotine.

What is Librium?

Librium has active ingredients of chlordiazepoxide hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 2,490 Librium users. Check the latest studies of Librium.

On Aug, 04, 2026

16 people who take Nicotine and Librium together, and have interactions are studied.

What are the common drug interactions of Nicotine and Librium, by gender? *:

female:

Drug ineffective
Hyperhidrosis (abnormally increased sweating)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Asthma
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Chronic respiratory failure
Cough
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)

male:

Face oedema (swelling of face)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Apnoea (suspension of external breathing)
Application site rash
Arthralgia (joint pain)
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Atrial tachycardia (rhythm disturbance that arises in the atria)

What are the common drug interactions of Nicotine and Librium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Suicidal ideation

30-39:

n/a

40-49:

Suicide attempt
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Asthma
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Chronic respiratory failure
Cough
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dyspnoea (difficult or laboured respiration)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)

50-59:

Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Face oedema (swelling of face)
Neck oedema (fluid collection in neck)
Respiratory distress (difficulty in breathing)
Tongue oedema (swelling of tongue)

60+:

Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Apnoea (suspension of external breathing)
Application site rash
Arthralgia (joint pain)
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)

What are the existing conditions these people have? *

High Blood Pressure: 4 people, 25.00%
Depression: 4 people, 25.00%
Drug Dependence: 3 people, 18.75%
Withdrawal Syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 2 people, 12.50%
Muscle Aches (muscle pain): 2 people, 12.50%
High Blood Cholesterol: 2 people, 12.50%
Heart Attack: 2 people, 12.50%
Back Disorder: 2 people, 12.50%
Abdominal Discomfort: 2 people, 12.50%
Panic Disorder: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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