Nicotine and Naltrexone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nicotine (nicotine) and Naltrexone (naltrexone). Common drug interactions include complication of device insertion among females and injury among males.

The phase IV clinical study analyzes what interactions people have when they take Nicotine and Naltrexone. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Nicotine?

Nicotine has active ingredients of nicotine. It is often used in quit smoking. eHealthMe is studying from 20,443 Nicotine users. Check the latest studies of Nicotine.

What is Naltrexone?

Naltrexone has active ingredients of naltrexone. eHealthMe is studying from 4,833 Naltrexone users. Check the latest studies of Naltrexone.

On May, 24, 2026

34 people who take Nicotine and Naltrexone together, and have interactions are studied.

Nicotine and Naltrexone drug interactions.

What are the common drug interactions of Nicotine and Naltrexone, by gender? *:

female:

Complication of device insertion
Cubital tunnel syndrome (a condition brought on by increased pressure on the ulnar nerve at the elbow)
Dental caries
Device expulsion
Drug dependence
Hospitalisation
Hypoaesthesia (reduced sense of touch or sensation)
Ill-defined disorder
Injection site pain
Injection site reaction

male:

Injury
Fatigue (feeling of tiredness)
Blood glucose increased
Boredom
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Crying
Dependence
Depressed mood
Emotional distress
Feeling jittery

What are the common drug interactions of Nicotine and Naltrexone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Weight decreased
Suicidal ideation
Ankle deformity
Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Borderline personality disorder
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Complication of device insertion
Cubital tunnel syndrome (a condition brought on by increased pressure on the ulnar nerve at the elbow)

30-39:

Beta haemolytic streptococcal infection (infection with streptococcus pyogenes, a beta-haemolytic bacterium cause mild to moderately severe respiratory tract, skin, and soft tissue)
Loss of consciousness
Necrosis ischaemic (death of cell due to lack of blood supply)
Pneumonia streptococcal (pneumonia, caused by streptococcus pneumoniae)
Septic shock (shock due to blood infection)
Abscess neck (neck abscesses)
Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

40-49:

Suicide attempt
Dysstasia (difficulty in standing)
Hypoaesthesia (reduced sense of touch or sensation)
Ill-defined disorder
Injection site pain
Injection site reaction
Injection site swelling
Muscle rupture (tear in muscle)
Myalgia (muscle pain)
Peripheral swelling

50-59:

Injury
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bone density decreased
Emotional distress
Osteoporosis (bones weak and more likely to break)
Pain
Spinal fracture (fracture in one of vertebrae)
Injection site pain
Injection site reaction
Osteopenia (a condition where bone mineral density is lower than normal)

60+:

Back pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Fall
Fatigue (feeling of tiredness)
Gait disturbance
Headache (pain in head)
Hip arthroplasty
Hypersomnia (excessive daytime sleepiness (eds))
Joint injury
Malaise (a feeling of general discomfort or uneasiness)

What are the existing conditions these people have? *

Bipolar Disorder (mood disorder): 4 people, 11.76%
Stress And Anxiety: 4 people, 11.76%
Alcoholism (problems with alcohol): 3 people, 8.82%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 8.82%
Pain: 3 people, 8.82%
Constipation: 3 people, 8.82%
Insomnia (sleeplessness): 3 people, 8.82%
Cough: 3 people, 8.82%
High Blood Pressure: 3 people, 8.82%
Diarrhea: 3 people, 8.82%

* Approximation only. Some reports may have incomplete information.

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