Nicotine and Valproic acid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nicotine (nicotine) and Valproic acid (valproic acid). Common drug interactions include white blood cell count decreased among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Nicotine and Valproic acid. It is created by eHealthMe based on reports of 77 people who take the same drugs from the FDA, and is updated regularly.

What is Nicotine?

Nicotine has active ingredients of nicotine. It is often used in quit smoking. eHealthMe is studying from 20,443 Nicotine users. Check the latest studies of Nicotine.

What is Valproic acid?

Valproic acid has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 36,193 Valproic acid users. Check the latest studies of Valproic acid.

On Jul, 21, 2026

77 people who take Nicotine and Valproic acid together, and have interactions are studied.

Nicotine and Valproic acid drug interactions.

What are the common drug interactions of Nicotine and Valproic Acid, by gender? *:

female:

White blood cell count decreased
Aspartate aminotransferase decreased
Blood alkaline phosphatase increased
Blood bilirubin decreased
Blood cholesterol increased
Blood glucose increased
Blood phosphorus increased
Blood prolactin increased
Haematocrit decreased
Mean cell haemoglobin concentration decreased (less concentration of haemoglobin in a given volume of packed red blood cells)

male:

Drug ineffective
Antipsychotic drug level increased
Constipation
Hypertension (high blood pressure)
Multiple drug overdose
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cardiomegaly (increased size of heart than normal)
Confusional state
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug toxicity

What are the common drug interactions of Nicotine and Valproic Acid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Drug ineffective

20-29:

Multiple drug overdose
Mean cell haemoglobin concentration decreased (less concentration of haemoglobin in a given volume of packed red blood cells)
Head injury
Aspartate aminotransferase decreased
Blood alkaline phosphatase increased
Blood bilirubin decreased
Blood cholesterol increased
Blood glucose increased
Blood phosphorus increased
Blood prolactin increased

30-39:

Mean cell volume decreased (less of the average red blood cell volume)
Red cell distribution width increased
Mean cell haemoglobin concentration decreased (less concentration of haemoglobin in a given volume of packed red blood cells)
Aspartate aminotransferase decreased
Blood alkaline phosphatase increased
Blood bilirubin decreased
Blood cholesterol increased
Blood glucose increased
Blood phosphorus increased
Blood prolactin increased

40-49:

Depressed mood
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Drug screen false positive
Drug toxicity
Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart)
Nephrosclerosis (hardening of the kidney due to renovascular disease)
Nervousness
Oedema peripheral (superficial swelling)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Pulmonary oedema (fluid accumulation in the lungs)

50-59:

Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Chest pain
Exostosis (formation of new bone on the surface of a bone)
Hyperlipidaemia (presence of excess lipids in the blood)
Hypertension (high blood pressure)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Tachyarrhythmia (disturbance of the heart rhythm in which the heart rate is abnormally increased)
Tinea pedis (a contagious skin infection caused by the ringworm fungus)
Cardiomegaly (increased size of heart than normal)
Coma (state of unconsciousness lasting more than six hours)

60+:

Constipation
Anaemia (lack of blood)
Somnolence (a state of near-sleep, a strong desire for sleep)
Weight decreased
Abdominal pain upper
Asthenia (weakness)
Ataxia (loss of full control of bodily movements)
Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)
Chest pain
Dementia (madness)

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 24 people, 31.17%
Mood Swings (an extreme or rapid change in mood): 10 people, 12.99%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 10 people, 12.99%
Bipolar Disorder (mood disorder): 8 people, 10.39%
Pain: 6 people, 7.79%
Dyspnea (difficult or laboured breathing): 5 people, 6.49%
Arrhythmias (irregular heartbeat): 5 people, 6.49%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 4 people, 5.19%
Constipation: 4 people, 5.19%

* Approximation only. Some reports may have incomplete information.

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