Nicotine and Zosyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nicotine (nicotine) and Zosyn (piperacillin sodium; tazobactam sodium). Common drug interactions include candidiasis among females and hypotension among males.

The phase IV clinical study analyzes what interactions people have when they take Nicotine and Zosyn. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Nicotine?

Nicotine has active ingredients of nicotine. It is often used in quit smoking. eHealthMe is studying from 20,443 Nicotine users. Check the latest studies of Nicotine.

What is Zosyn?

Zosyn has active ingredients of piperacillin sodium; tazobactam sodium. It is often used in pneumonia. eHealthMe is studying from 10,236 Zosyn users. Check the latest studies of Zosyn.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

64 people who take Nicotine and Zosyn together, and have interactions are studied.

What are the common drug interactions of Nicotine and Zosyn, by gender? *:

female:

Candidiasis (candidiasis or thrush is a fungal infection)
Cardiogenic shock (inadequate circulation of blood)
Cardiomyopathy (weakening of the heart muscle)
Cellulitis (infection under the skin)
Enterococcal infection
Hyperkalaemia (damage to or disease of the kidney)
Influenza
Malignant pleural effusion (a condition in which cancer causes an abnormal amount of fluid to collect between the thin layers of tissue lining of lung)
Multi-organ failure (multisystem organ failure)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)

male:

Hypotension (abnormally low blood pressure)
Sepsis (a severe blood infection that can lead to organ failure and death)
Abscess limb (limb infection)
Cellulitis of male external genital organ (infection of male genitals soft tissue)
Hydrocele
Necrosis (the death of body tissue)
Orchitis (inflammation of the testes)
Rash erythematous (redness of the skin)
Rash generalised (rash on most of body parts)
Rash pruritic (redness with itching)

What are the common drug interactions of Nicotine and Zosyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Antibiotic level above therapeutic

30-39:

Chronic kidney disease
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Confusional state
Drug ineffective
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Myasthenic syndrome (a group of conditions characterized by muscle weakness (myasthenia) that worsens with physical exertion)
Nausea (feeling of having an urge to vomit)

40-49:

Sepsis (a severe blood infection that can lead to organ failure and death)
Abscess limb (limb infection)
Cellulitis (infection under the skin)
Subcutaneous abscess
Urinary tract infection
Bradycardia (abnormally slow heart action)
Left ventricular dysfunction
Pleural effusion (water on the lungs)
Respiratory failure (inadequate gas exchange by the respiratory system)
Unresponsive to stimuli

50-59:

Renal tubular necrosis (death of kidney tubules)
Respiratory failure (inadequate gas exchange by the respiratory system)
Seborrhoeic dermatitis (a common, inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp)
Tendonitis (a condition that causes pain and swelling of tendons)
Thermal burn (burn by heat)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Vulval abscess
Leukocytosis (increased white blood cells)
Rash generalised (rash on most of body parts)
Renal failure acute (rapid kidney dysfunction)

60+:

Sepsis (a severe blood infection that can lead to organ failure and death)
Pyrexia (fever)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Abdominal pain
Asthenia (weakness)
Back pain
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chills (felling of cold)
Chronic kidney disease
Colon injury

What are the existing conditions these people have? *

Pain: 18 people, 28.12%
Type 2 Diabetes: 14 people, 21.88%
High Blood Pressure: 13 people, 20.31%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 15.62%
Stress And Anxiety: 8 people, 12.50%
Insomnia (sleeplessness): 8 people, 12.50%
Nausea (feeling of having an urge to vomit): 7 people, 10.94%
Weight Decreased: 7 people, 10.94%
Cellulitis (infection under the skin): 6 people, 9.38%
Fever: 5 people, 7.81%

* Approximation only. Some reports may have incomplete information.

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