Nicotinic acid and Melatonin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nicotinic acid (niacin and niacinamide (vitamin b3)) and Melatonin (melatonin). Common drug interactions include abdominal pain upper among females and somnolence among males.

The phase IV clinical study analyzes what interactions people have when they take Nicotinic acid and Melatonin. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Nicotinic acid?

Nicotinic acid has active ingredients of niacin and niacinamide (vitamin b3). It is often used in high blood cholesterol. eHealthMe is studying from 842 Nicotinic acid users. Check the latest studies of Nicotinic acid.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

On Jul, 26, 2026

14 people who take Nicotinic acid and Melatonin together, and have interactions are studied.

Nicotinic acid and Melatonin drug interactions.

What are the common drug interactions of Nicotinic Acid and Melatonin, by gender? *:

female:

Abdominal pain upper
Asthenia (weakness)
Bedridden
Cushingoid (obesity and weakening of the muscles)
Depression
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Exostosis (formation of new bone on the surface of a bone)
Fatigue (feeling of tiredness)
Fibromyalgia (a long-term condition which causes pain all over the body)

male:

Somnolence (a state of near-sleep, a strong desire for sleep)
Abdominal discomfort
Ascites (accumulation of fluid in the abdominal cavity)
Cardiogenic shock (inadequate circulation of blood)
Constipation
General physical health deterioration (weak health status)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Sepsis (a severe blood infection that can lead to organ failure and death)

What are the common drug interactions of Nicotinic Acid and Melatonin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal pain upper
Asthenia (weakness)
Bedridden
Cushingoid (obesity and weakening of the muscles)
Depression
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Exostosis (formation of new bone on the surface of a bone)
Fatigue (feeling of tiredness)
Fibromyalgia (a long-term condition which causes pain all over the body)

50-59:

Abdominal discomfort
Arthralgia (joint pain)
Diarrhoea
Fatigue (feeling of tiredness)
Pain in extremity
Peripheral swelling
Somnolence (a state of near-sleep, a strong desire for sleep)
Muscle spasms (muscle contraction)
Abdominal pain upper
Gastrointestinal disorder (functional problems of gastrointestinal tract)

60+:

Abdominal distension
Abdominal pain
Stress
Ventricular fibrillation (abnormally irregular heart rhythm)
Vomiting
Blood phosphorus increased
Death
Blood uric acid increased
Dry mouth
Myasthenia gravis (a chronic condition that causes muscles to tire and weaken easily)

What are the existing conditions these people have? *

Acromegaly (body produces too much growth hormone, leading to excess growth of body tissues): 6 people, 42.86%
Adrenal Insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids): 4 people, 28.57%
Thrombosis (formation of a blood clot inside a blood vessel): 3 people, 21.43%
Anaemia (lack of blood): 3 people, 21.43%
Bacterial Infection: 3 people, 21.43%
Blood Phosphorus Increased: 3 people, 21.43%
Blood Uric Acid Increased: 3 people, 21.43%
Cardiogenic Shock (inadequate circulation of blood): 3 people, 21.43%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 3 people, 21.43%
Constipation: 3 people, 21.43%

* Approximation only. Some reports may have incomplete information.

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