Probenecid and Neurontin drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Probenecid (probenecid) and Neurontin (gabapentin). Common drug interactions include rheumatoid arthritis among females and anxiety among males.
The phase IV clinical study analyzes what interactions people have when they take Probenecid and Neurontin. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.
What is Probenecid?
Probenecid has active ingredients of probenecid. It is often used in gout. eHealthMe is studying from 560 Probenecid users. Check the latest studies of Probenecid.
What is Neurontin?
Neurontin has active ingredients of gabapentin. It is often used in neuralgia. eHealthMe is studying from 107,468 Neurontin users. Check the latest studies of Neurontin.
21 people who take Probenecid and Neurontin together, and have interactions are studied.

What are the common drug interactions of Probenecid and Neurontin, by gender? *:
female:
- Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
- Anxiety
- Bladder dilatation
- Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
- Chronic kidney disease
- Constipation
- Depression
- Gastric ulcer (stomach ulcer)
- Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
- Haemoglobin decreased
male:
- Anxiety
- Bone pain
- Swelling
- Arteriosclerosis (thickening and hardening of arteries)
- Arteriovenous fistula
- Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
- Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
- Device related infection
- Gastritis (inflammation of stomach)
- Hyperkalaemia (damage to or disease of the kidney)
What are the common drug interactions of Probenecid and Neurontin, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
n/a
50-59:
- Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
- Chronic kidney disease
- Depression
- Injury
- Lung cancer metastatic (lung cancer spreads to other parts)
- Nephrogenic anaemia (anaemia due to kidney disease)
- Pulmonary mass
- Renal failure (kidney dysfunction)
- Renal tubular necrosis (death of kidney tubules)
- Tooth abscess (pus formation in tooth)
60+:
- Cardiac failure congestive
- Anxiety
- Anhedonia (inability to experience pleasure from activities usually found enjoyable)
- Arteriosclerosis (thickening and hardening of arteries)
- Arteriovenous fistula
- Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
- Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
- Device related infection
- Disability
- Gastritis (inflammation of stomach)
What are the existing conditions these people have? *
- Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 14.29%
- Multiple Myeloma (cancer of the plasma cells): 2 people, 9.52%
- Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 2 people, 9.52%
- Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 9.52%
* Approximation only. Some reports may have incomplete information.
Do you take Probenecid and Neurontin?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Probenecid (560 reports)
- Neurontin (107,468 reports)
Browse all drug interactions of Probenecid and Neurontin:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Probenecid:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Neurontin:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Probenecid and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Neurontin and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- de Landaluce, L. O., Carbonell, P., Asensio, C., Escoda, N., López, P., & Laporte, J. R. , "Gabapentin and Pregabalin and Risk of Atrial Fibrillation in the Elderly: A Population-Based Cohort Study in an Electronic Prescription Database", Drug safety, 2018 Jan .
- Scarff JR, "The Potential for Somnambulism Associated with Gabapentin", The Internet Journal of Psychiatry, 2014 Jan .
- de Landaluce, L. O., Carbonell, P., Asensio, C., Escoda, N., López, P., & Laporte, J. R. , "Gabapentin and Pregabalin and Risk of Atrial Fibrillation in the Elderly: A Population-Based Cohort Study in an Electronic Prescription Database", Drug safety, 2018 Jan .
- Scarff JR, "The Potential for Somnambulism Associated with Gabapentin", The Internet Journal of Psychiatry, 2014 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on probenecid and gabapentin (the active ingredients of Probenecid and Neurontin, respectively), and Probenecid and Neurontin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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