Nicotrol and Hydramine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nicotrol (nicotine) and Hydramine (diphenhydramine hydrochloride). Common drug interactions include headache among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Nicotrol and Hydramine. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Nicotrol?

Nicotrol has active ingredients of nicotine. eHealthMe is studying from 4,104 Nicotrol users. Check the latest studies of Nicotrol.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

On Jul, 11, 2026

12 people who take Nicotrol and Hydramine together, and have interactions are studied.

Nicotrol and Hydramine drug interactions.

What are the common drug interactions of Nicotrol and Hydramine, by gender? *:

female:

Headache (pain in head)
Osteoporosis (bones weak and more likely to break)
Rash
Tibia fracture (fracture of lower leg bone)
Abdominal pain
Abdominal pain upper
Acne (skin problems that cause pimples)
Activities of daily living impaired
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Alopecia (absence of hair from areas of the body)

male:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Parkinsonism (degenerative disorder of the central nervous system characterized by tremor and impaired muscular coordination)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)

What are the common drug interactions of Nicotrol and Hydramine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Parkinsonism (degenerative disorder of the central nervous system characterized by tremor and impaired muscular coordination)

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Foot fracture
Hospitalisation
Osteoporosis (bones weak and more likely to break)
Pain
Tibia fracture (fracture of lower leg bone)
Vitamin d decreased

50-59:

Migraine (headache)
Nephrogenic anaemia (anaemia due to kidney disease)
Nicotine dependence
Oral disorder (mouth disease)
Rash
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Skin exfoliation (removal of the oldest dead skin cells)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Alopecia (absence of hair from areas of the body)

60+:

Drug dependence
Nausea (feeling of having an urge to vomit)
Throat irritation

What are the existing conditions these people have? *

Quit Smoking: 6 people, 50.00%
Nausea (feeling of having an urge to vomit): 4 people, 33.33%
Pain: 3 people, 25.00%
Diabetes: 3 people, 25.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 25.00%
High Blood Cholesterol: 2 people, 16.67%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 2 people, 16.67%
Inflammation: 2 people, 16.67%
Viral Infection: 2 people, 16.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 16.67%

* Approximation only. Some reports may have incomplete information.

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