Norco and Optimark drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norco (acetaminophen; hydrocodone bitartrate) and Optimark (gadoversetamide). Common drug interactions include nephrogenic systemic fibrosis among females and joint range of motion decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Norco and Optimark. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Norco?

Norco has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 74,063 Norco users. Check the latest studies of Norco.

What is Optimark?

Optimark has active ingredients of gadoversetamide. eHealthMe is studying from 3,055 Optimark users. Check the latest studies of Optimark.

On Jul, 11, 2026

45 people who take Norco and Optimark together, and have interactions are studied.

What are the common drug interactions of Norco and Optimark, by gender? *:

female:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Skin hypertrophy (skin cells enlarges)
Skin tightness
Joint range of motion decreased (disease of joint movement)
Oedema peripheral (superficial swelling)
Skin induration (an abnormally hard spot or area on the skin)
Mobility decreased (ability to move is reduced)
Deformity (disfigurement)
Scar
Skin fibrosis (fibrous tissue formation on skin)

male:

Joint range of motion decreased (disease of joint movement)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Joint contracture (a permanent shortening of a muscle or joint)
Neuropathic arthropathy (a progressive destruction of bone and joints)
Oedema (fluid collection in tissue)
Post inflammatory pigmentation change
Rash generalised (rash on most of body parts)
Skin exfoliation (removal of the oldest dead skin cells)
Skin ulcer
Stasis dermatitis (skin inflammation caused by blood pooling in the veins in your legs)

What are the common drug interactions of Norco and Optimark, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anxiety
Emotional distress
General physical health deterioration (weak health status)
Joint contracture (a permanent shortening of a muscle or joint)
Joint range of motion decreased (disease of joint movement)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Skin hypertrophy (skin cells enlarges)
Skin induration (an abnormally hard spot or area on the skin)
Skin tightness
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

50-59:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Skin tightness
Scar
Joint stiffness
Pain of skin
Skin exfoliation (removal of the oldest dead skin cells)
Erythema (redness of the skin)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Skin hyperpigmentation (disorders affect the colour of your skin)
Activities of daily living impaired

60+:

n/a

What are the existing conditions these people have? *

Nuclear Magnetic Resonance Imaging Brain: 25 people, 55.56%
Depression: 14 people, 31.11%
Stress And Anxiety: 12 people, 26.67%
High Blood Cholesterol: 12 people, 26.67%
Device Related Infection: 12 people, 26.67%
Herpes Zoster: 12 people, 26.67%
Gastritis Erosive (a break in the surface layer of the membrane lining the stomach with infection): 12 people, 26.67%
Itching: 12 people, 26.67%
Nausea (feeling of having an urge to vomit): 12 people, 26.67%
Nuclear Magnetic Resonance Imaging Abdominal: 8 people, 17.78%

* Approximation only. Some reports may have incomplete information.

Do you take Norco and Optimark?

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