Norco and Zegerid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norco (acetaminophen; hydrocodone bitartrate) and Zegerid (omeprazole; sodium bicarbonate). Common drug interactions include carbon dioxide decreased among females and chronic obstructive pulmonary disease among males.

The phase IV clinical study analyzes what interactions people have when they take Norco and Zegerid. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Norco?

Norco has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 74,063 Norco users. Check the latest studies of Norco.

What is Zegerid?

Zegerid has active ingredients of omeprazole; sodium bicarbonate. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 3,220 Zegerid users. Check the latest studies of Zegerid.

On Jul, 05, 2026

40 people who take Norco and Zegerid together, and have interactions are studied.

What are the common drug interactions of Norco and Zegerid, by gender? *:

female:

Carbon dioxide decreased
Constipation
Coombs test positive
Disease recurrence
Eosinophil percentage increased
Haematocrit decreased
Haemoglobin decreased
Iron binding capacity total decreased
Lymphocyte count decreased
Lymphocyte percentage decreased

male:

Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Bone marrow failure
Portal hypertension (increase in the blood pressure within a system of veins called the portal venous system)
Post procedural haemorrhage (post procedural bleeding)
Rib fracture
Thrombocytopenia (decrease of platelets in blood)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Chest pain

What are the common drug interactions of Norco and Zegerid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abortion induced (medically referred abortion)
Anxiety
Deafness
Depression
Disturbance in attention
Facial pain
Headache (pain in head)
Injury
Intracranial venous sinus thrombosis (presence of thrombosis (a blood clot) in the dural venous sinuses, which drain blood from the brain)
Jugular vein thrombosis (clot in jugular vein)

30-39:

n/a

40-49:

Acute myocardial infarction (acute heart attack)
Alanine aminotransferase increased
Anion gap increased
Arthralgia (joint pain)
Basophil percentage increased
Blood albumin decreased
Blood calcium decreased
Blood chloride increased
Blood folate increased
Blood glucose increased

50-59:

Hot flush (sudden feelings of heat)
Hyperhidrosis (abnormally increased sweating)
Pain in extremity
Chronic kidney disease
Glomerular vascular disorder (disease primarily affecting the blood vessels of glomerular)
Nephrosclerosis (hardening of the kidney due to renovascular disease)
Renal injury (kidney injury)
Renal tubular necrosis (death of kidney tubules)
Blood disorder
Drug effect decreased

60+:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Death
Renal failure (kidney dysfunction)
Contusion (a type of hematoma of tissue in which capillaries)
Dizziness
Nausea (feeling of having an urge to vomit)
Rib fracture
Asthenia (weakness)
Bone marrow failure

What are the existing conditions these people have? *

Stress And Anxiety: 8 people, 20.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 20.00%
Depression: 8 people, 20.00%
High Blood Pressure: 8 people, 20.00%
Nausea (feeling of having an urge to vomit): 8 people, 20.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 17.50%
Muscle Spasms (muscle contraction): 5 people, 12.50%
Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 10.00%
Nausea And Vomiting: 4 people, 10.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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