Norepinephrine bitartrate and Spironolactone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norepinephrine bitartrate (norepinephrine bitartrate) and Spironolactone (spironolactone). Common drug interactions include oxygen saturation decreased among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Norepinephrine bitartrate and Spironolactone. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Norepinephrine bitartrate?

Norepinephrine bitartrate has active ingredients of norepinephrine bitartrate. eHealthMe is studying from 2,370 Norepinephrine bitartrate users. Check the latest studies of Norepinephrine bitartrate.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,947 Spironolactone users. Check the latest studies of Spironolactone.

On Jul, 08, 2026

60 people who take Norepinephrine bitartrate and Spironolactone together, and have interactions are studied.

Norepinephrine bitartrate and Spironolactone drug interactions.

What are the common drug interactions of Norepinephrine Bitartrate and Spironolactone, by gender? *:

female:

Oxygen saturation decreased
Pulmonary oedema (fluid accumulation in the lungs)
Septic shock (shock due to blood infection)
Bradycardia (abnormally slow heart action)
Burkholderia test positive
Cough
Dyspnoea (difficult or laboured respiration)
Loss of consciousness
Neutropenia (an abnormally low number of neutrophils)
Neutropenic infection (infection with less neutrophil numbers in blood)

male:

Pneumonia
Respiratory failure (inadequate gas exchange by the respiratory system)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Cardiac output decreased
Cardiogenic shock (inadequate circulation of blood)
Cerebellar ischaemia (lack of blood supply to cerebeller)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Haematoma (collection of blood outside the blood vessels)
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)

What are the common drug interactions of Norepinephrine Bitartrate and Spironolactone, by age (0-1 to 60+)? *:

0-1:

Drug ineffective

2-9:

Bradycardia (abnormally slow heart action)
Oxygen saturation decreased
Respiratory failure (excl neonatal) (inadequate gas exchange by the respiratory system(excluding neonatal))
Sepsis (a severe blood infection that can lead to organ failure and death)

10-19:

n/a

20-29:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Chest pain
Diarrhoea
Headache (pain in head)
Liver disorder (liver diseases)
Oxygen saturation decreased
Palpitations (feelings or sensations that your heart is pounding or racing)
Platelet count decreased
Pulmonary oedema (fluid accumulation in the lungs)

30-39:

n/a

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Death
Emotional distress
Fear
Injury
Multi-organ failure (multisystem organ failure)
Pain
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)

50-59:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematoma (collection of blood outside the blood vessels)
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Hepatic failure (liver failure)
Liver disorder (liver diseases)
Pneumonia
Pulmonary hypertension (increase in blood pressure in the lung artery)

60+:

Pneumonia
Respiratory failure (inadequate gas exchange by the respiratory system)
Macule (a discoloured spot on the skin)
Radiation pneumonitis (inflammation of lung due to radiation)
Renal injury (kidney injury)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Emotional distress
Loss of consciousness
Multi-organ failure (multisystem organ failure)

What are the existing conditions these people have? *

Hypotension (abnormally low blood pressure): 11 people, 18.33%
High Blood Pressure: 9 people, 15.00%
Sedation: 8 people, 13.33%
Pain: 8 people, 13.33%
Urination - Excessive Volume: 7 people, 11.67%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 6 people, 10.00%
Local Anaesthesia: 5 people, 8.33%
Asthma: 5 people, 8.33%
Haemorrhage (bleeding): 4 people, 6.67%
Enlarged Prostate: 4 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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