Norflex and Buspar drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norflex (orphenadrine citrate) and Buspar (buspirone hydrochloride). Common drug interactions include arthritis among females and insomnia among males.

The phase IV clinical study analyzes what interactions people have when they take Norflex and Buspar. It is created by eHealthMe based on reports of 54 people who take the same drugs from the FDA, and is updated regularly.

What is Norflex?

Norflex has active ingredients of orphenadrine citrate. It is often used in muscle spasms. eHealthMe is studying from 1,951 Norflex users. Check the latest studies of Norflex.

What is Buspar?

Buspar has active ingredients of buspirone hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 20,462 Buspar users. Check the latest studies of Buspar.

On Jul, 17, 2026

54 people who take Norflex and Buspar together, and have interactions are studied.

What are the common drug interactions of Norflex and Buspar, by gender? *:

female:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Breast cancer
Breast pain
Cervicobrachial syndrome (pain in neck and arm with changing location)
Chronic fatigue syndrome (disorder that causes extreme fatigue)
Dizziness
Epigastric discomfort
Fall
Hot flush (sudden feelings of heat)
Intervertebral disc disorder (spinal disc disorder)

male:

Insomnia (sleeplessness)
Agitation (state of anxiety or nervous excitement)
Tremor (trembling or shaking movements in one or more parts of your body)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Acute psychosis (period of mentally unstable behaviour)
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Chest pain
Emotional distress
Rash
Arthralgia (joint pain)

What are the common drug interactions of Norflex and Buspar, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Drug addiction
Chronic kidney disease
Coma (state of unconsciousness lasting more than six hours)
Detoxification
Drug abuser
Drug screen positive
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dyspepsia (indigestion)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hemiplegia (paralysis of one side of the body)

40-49:

Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Rash
Oedema peripheral (superficial swelling)
Acute psychosis (period of mentally unstable behaviour)
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Drug ineffective
Emotional distress
Muscle contractions involuntary (uncontrolled muscle contraction)
Abdominal pain
Blood pressure increased

50-59:

Hypertension (high blood pressure)
Asthenia (weakness)
Headache (pain in head)
Arthralgia (joint pain)
Palpitations (feelings or sensations that your heart is pounding or racing)
Arteriosclerosis (thickening and hardening of arteries)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Breast cancer
Breast pain
Cervicobrachial syndrome (pain in neck and arm with changing location)

60+:

Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Benign middle ear neoplasm (benign (non-cancerous) tumours of the liver)
Hypotension (abnormally low blood pressure)
Joint stiffness
Limb discomfort (discomfort in leg)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nausea (feeling of having an urge to vomit)
Respiratory rate increased (excess breathing rate/min)
Tremor (trembling or shaking movements in one or more parts of your body)

What are the existing conditions these people have? *

Pain: 16 people, 29.63%
Menopause (end of monthly cycles in women): 7 people, 12.96%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 7 people, 12.96%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 9.26%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 3 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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