Norflex and Desyrel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norflex (orphenadrine citrate) and Desyrel (trazodone hydrochloride). Common drug interactions include breast pain among females and disseminated tuberculosis among males.

The phase IV clinical study analyzes what interactions people have when they take Norflex and Desyrel. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Norflex?

Norflex has active ingredients of orphenadrine citrate. It is often used in muscle spasms. eHealthMe is studying from 1,951 Norflex users. Check the latest studies of Norflex.

What is Desyrel?

Desyrel has active ingredients of trazodone hydrochloride. It is often used in insomnia. eHealthMe is studying from 6,595 Desyrel users. Check the latest studies of Desyrel.

On Jul, 08, 2026

15 people who take Norflex and Desyrel together, and have interactions are studied.

What are the common drug interactions of Norflex and Desyrel, by gender? *:

female:

Breast pain
Cervicobrachial syndrome (pain in neck and arm with changing location)
Chronic fatigue syndrome (disorder that causes extreme fatigue)
Dizziness
Dyspnoea (difficult or laboured respiration)
Epigastric discomfort
Fall
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Headache (pain in head)

male:

Disseminated tuberculosis
Histoplasmosis (infection caused by breathing in spores of a fungus)
Pulmonary tuberculosis (lungs tuberculosis)
Tuberculosis gastrointestinal (a bacterial infection of digestive tract by mycobacterium tuberculosis)

What are the common drug interactions of Norflex and Desyrel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cellulitis (infection under the skin)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Drug addiction
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Heart rate increased
Hypertension (high blood pressure)
Road traffic accident

40-49:

Cough
Haemoglobin decreased
Oedema peripheral (superficial swelling)
Oropharyngeal pain
Red blood cell count decreased
Alopecia (absence of hair from areas of the body)
Arteriosclerosis (thickening and hardening of arteries)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)

50-59:

Arteriosclerosis (thickening and hardening of arteries)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Breast cancer
Breast pain
Cervicobrachial syndrome (pain in neck and arm with changing location)
Chronic fatigue syndrome (disorder that causes extreme fatigue)
Dizziness
Dyspnoea (difficult or laboured respiration)

60+:

Acarodermatitis (skin inflammation caused by mites (acarids))
Blood pressure increased
Mobility decreased (ability to move is reduced)
Nodule (a growth of abnormal tissue)
Overweight
Pruritus (severe itching of the skin)
Rash
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Sciatic nerve neuropathy (sciatic nerve damage)
Sepsis (a severe blood infection that can lead to organ failure and death)

What are the existing conditions these people have? *

Menopause (end of monthly cycles in women): 7 people, 46.67%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 7 people, 46.67%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 20.00%
Pain: 2 people, 13.33%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 1 person, 6.67%
Bipolar Ii Disorder (characterized by at least one episode of hypomania and at least one episode of major depression): 1 person, 6.67%
Blood Pressure Abnormal: 1 person, 6.67%
Depression: 1 person, 6.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 6.67%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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