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Norflex and Diclofenac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norflex (orphenadrine citrate) and Diclofenac (diclofenac). Common drug interactions include gastrooesophageal reflux disease among females and anxiety disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Norflex and Diclofenac. It is created by eHealthMe based on reports of 86 people who take the same drugs from the FDA, and is updated regularly.

What is Norflex?

Norflex has active ingredients of orphenadrine citrate. It is often used in muscle spasms. eHealthMe is studying from 1,951 Norflex users. Check the latest studies of Norflex.

What is Diclofenac?

Diclofenac has active ingredients of diclofenac. eHealthMe is studying from 41,319 Diclofenac users. Check the latest studies of Diclofenac.

On Jul, 13, 2026

86 people who take Norflex and Diclofenac together, and have interactions are studied.

Norflex and Diclofenac drug interactions.

What are the common drug interactions of Norflex and Diclofenac, by gender? *:

female:

  1. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  2. Diarrhoea
  3. Hypoaesthesia (reduced sense of touch or sensation)
  4. Sternal fracture
  5. Libido increased (increased sexual urge to have sex)
  6. Weight decreased
  7. Somnolence (a state of near-sleep, a strong desire for sleep)
  8. Anxiety
  9. Body temperature increased
  10. Dizziness

male:

  1. Anxiety disorder
  2. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  3. Pruritus (severe itching of the skin)
  4. Quality of life decreased
  5. Abdominal discomfort
  6. Constipation
  7. Vomiting
  8. Cough
  9. Depression
  10. Emotional distress

What are the common drug interactions of Norflex and Diclofenac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  2. Diarrhoea
  3. Dysgeusia (disorder of the sense of taste)
  4. Dyspepsia (indigestion)
  5. Feeling hot
  6. Flushing (the warm, red condition of human skin)
  7. Headache (pain in head)
  8. Hostility
  9. Hyperhidrosis (abnormally increased sweating)
  10. Irritability

60+:

n/a

What are the existing conditions these people have? *

  1. Migraine (headache): 80 people, 93.02%
  2. Depression: 79 people, 91.86%
  3. Pain: 26 people, 30.23%

* Approximation only. Some reports may have incomplete information.

Do you take Norflex and Diclofenac?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Norflex and Diclofenac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Norflex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Diclofenac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Norflex and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Diclofenac and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on orphenadrine citrate and diclofenac (the active ingredients of Norflex and Diclofenac, respectively), and Norflex and Diclofenac (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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