Norflex and Excedrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norflex (orphenadrine citrate) and Excedrin (acetaminophen; aspirin; caffeine). Common drug interactions include depression among females.

The phase IV clinical study analyzes what interactions people have when they take Norflex and Excedrin. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Norflex?

Norflex has active ingredients of orphenadrine citrate. It is often used in muscle spasms. eHealthMe is studying from 1,951 Norflex users. Check the latest studies of Norflex.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

On Jul, 29, 2026

11 people who take Norflex and Excedrin together, and have interactions are studied.

What are the common drug interactions of Norflex and Excedrin, by gender? *:

female:

Depression
Drug hypersensitivity
Malaise (a feeling of general discomfort or uneasiness)
Psoriasis (immune-mediated disease that affects the skin)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Sinusitis (inflammation of sinus)
Vitamin d deficiency
Abdominal pain
Abdominal pain lower

male:

n/a

What are the common drug interactions of Norflex and Excedrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Drug hypersensitivity
Abdominal pain
Cardiac failure congestive
Chest pain
Concussion (short loss of normal brain function in response to a head injury)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Depression
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Diarrhoea
Dizziness

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 27.27%
Psoriasis (immune-mediated disease that affects the skin): 3 people, 27.27%
Gout (uric acid crystals building up in the body): 3 people, 27.27%
Seasonal Allergy (allergic condition due to certain season): 2 people, 18.18%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 18.18%
Neuralgia (pain in one or more nerves): 2 people, 18.18%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 2 people, 18.18%
Muscle Tightness: 2 people, 18.18%
Migraine (headache): 2 people, 18.18%
Hyperchlorhydria (gastric acid levels are higher in stomach): 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

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